| Influence of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors on the central nervous system activity in mice. | |
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MedLine Citation:
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PMID: 11985348 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The present study investigated the influence of BM-78, BM-121 (gamma-aminobutyric acid amide derivatives) and BM-42, BM-43 (phthalimide precursors of BM-78 and BM-121) on the spontaneous locomotor activity and on the picrotoxin-induced seizures. Results of pharmacological in vivo examination of the effects of new gamma-aminobutyric acid amide derivatives and its phthalimide precursors (compounds BM-78, BM-121, BM-42, BM-43), presented in this paper showed that all the compounds had different but clear influence on CNS in mice. |
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Authors:
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A Mendyk; K Sałat; T Librowski; R Czarneck; B Malawska |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Polish journal of pharmacology Volume: 53 ISSN: 1230-6002 ISO Abbreviation: Pol J Pharmacol Publication Date: 2001 Nov-Dec |
Date Detail:
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Created Date: 2002-05-02 Completed Date: 2002-07-19 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 9313882 Medline TA: Pol J Pharmacol Country: Poland |
Other Details:
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Languages: eng Pagination: 689-93 Citation Subset: IM |
Affiliation:
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Department of Pharmacodynamics, Jagiellonian University, Medical College, Kraków, Poland. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anticonvulsants / pharmacology* Brain / drug effects* GABA Antagonists Male Mice Motor Activity / drug effects Phthalimides / chemistry, pharmacology* Picrotoxin Seizures / chemically induced, prevention & control gamma-Aminobutyric Acid / analogs & derivatives*, chemistry, pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/GABA Antagonists; 0/Phthalimides; 124-87-8/Picrotoxin; 56-12-2/gamma-Aminobutyric Acid |
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