Document Detail

Influence of nephrectomy on the growth of a murine Wilms tumor: a study using parabiotic rats.
MedLine Citation:
PMID:  2165186     Owner:  NLM     Status:  MEDLINE    
It has been reported that unilateral nephrectomy causes acceleration of the growth of a Wistar/Furth rat Wilms tumor. We studied this phenomenon in parabiotic rats by measuring tumor growth after either sham nephrectomy, or excision of 1, 2 or 3 kidneys. We observed no stimulation of tumor growth in the experimental groups. Renal function was significantly decreased after removal of 2 or 3 kidneys. Serum creatinine levels were significantly different between right and left members of parabiotic pairs in these 2 groups. The effect of unilateral and bilateral nephrectomy on tumor growth in single rats also was examined. In these rats progressive increases in tumor growth were observed after unilateral and bilateral nephrectomy. Our inability to demonstrate a tumor-stimulating factor in the parabiotic model may be due partly to incomplete sharing of humoral factors between parabionts. Serum transfer studies in vitro may prove more fruitful in demonstrating such a factor.
J C Trindade; M C Rangel; J H Ross; K Jojima; N T Stowe; R Kay; J E Pontes
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of urology     Volume:  144     ISSN:  0022-5347     ISO Abbreviation:  J. Urol.     Publication Date:  1990 Aug 
Date Detail:
Created Date:  1990-08-30     Completed Date:  1990-08-30     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0376374     Medline TA:  J Urol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  418-21; discussion 422     Citation Subset:  AIM; IM    
Department of Urology, Cleveland Clinic Foundation, Ohio.
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MeSH Terms
Creatinine / metabolism
Glomerular Filtration Rate
Inulin / diagnostic use
Kidney Function Tests
Kidney Neoplasms / pathology*,  physiopathology
Rats, Inbred WF
Wilms Tumor / pathology*,  physiopathology
Reg. No./Substance:
60-27-5/Creatinine; 9005-80-5/Inulin

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