Document Detail

Influence of nebivolol on endothelial dysfunction in salt-sensitive hypertension.
MedLine Citation:
PMID:  16705229     Owner:  NLM     Status:  MEDLINE    
The study was aimed to assess influence of nebivolol (nebilet) on endothelial factors (NO and endothelin1) during treatment of salt-sensitive hypertensive patients. A total of 40 patients (18 females and 22 males, mean age 53,1+/-1,58 yrs) with mild (I stage) arterial hypertension (with diastolic pressure 90-99 mm Hg and/or systolic pressure 140-159 mm Hg) were studied. Twelve age matched healthy subjects (4 women and 8 males) composed control group. Salt sensitivity was detected by M. Weir (1993) method. Patients were divided in two groups: salt sensitive hypertension (group I, 16 patients) and salt-resistant hypertension (group II, 24 patients). Nebivolol (Nebilet, Berlin-Chemie, Germany) was administered to 25 patients in dosage of 5 mg once a day during two weeks. Our studies have showed that ET-1 plasma levels were significantly elevated in patients with essential hypertension, while NO was markedly reduced compared to control group. NO levels were slightly lower in salt-sensitive hypertensives than in salt-resistant patients (p>0,05). ET-1 levels expressed opposite changes: in patients with salt-sensitive hypertension ET-1 levels almost twice exceeded those of salt-resistant patients (p<0,01). After treatment with nebivolol NO plasma level in salt-sensitive hypertensives significantly increased in Group I and did not change significantly in salt-resistant patients. Only slight decrease in ET-1 levels was detected in both groups after taking nebilet. Nebilet (nebivolol) treatment has an influence only on NO levels and appears to be the most effective in salt-sensitive hypertension.
J Ugrekhelidze; G Simonia; I Andronikashvili; M Kutateladze
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Georgian medical news     Volume:  -     ISSN:  1512-0112     ISO Abbreviation:  Georgian Med News     Publication Date:  2006 Apr 
Date Detail:
Created Date:  2006-05-17     Completed Date:  2006-07-17     Revised Date:  2009-11-03    
Medline Journal Info:
Nlm Unique ID:  101218222     Medline TA:  Georgian Med News     Country:  Georgia (Republic)    
Other Details:
Languages:  eng     Pagination:  56-8     Citation Subset:  IM    
Department of Internal Medicine, Tbilisi State Medical University.
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MeSH Terms
Benzopyrans / pharmacology*,  therapeutic use
Endothelium, Vascular / drug effects*
Ethanolamines / pharmacology*,  therapeutic use
Hypertension* / drug therapy,  epidemiology,  metabolism
Middle Aged
Nitric Oxide / blood
Sodium / metabolism*
Vasodilator Agents / pharmacology*,  therapeutic use
Reg. No./Substance:
0/Benzopyrans; 0/Ethanolamines; 0/Vasodilator Agents; 10102-43-9/Nitric Oxide; 7440-23-5/Sodium; 99200-09-6/nebivolol

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