| Influence of natural and synthetic histone deacetylase inhibitors on chromatin. | |
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MedLine Citation:
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PMID: 22229817 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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Histone deacetylase inhibitors (HDACI) have emerged as a new class of anticancer therapeutics. The hydroxamic acid, suberoylanilide hyroxamic acid (Vorinostat, Zolinza™) and the cyclic peptide, depsipeptide (Romidepsin, Istodax™) were approved by the US Food and Drug Administration (FDA) for the treatment of cutaneous T-cell lymphoma in 2006 and 2009, respectively. At least 15 HDACI are currently undergoing clinical trials either alone or in combination with other therapeutic modalities for the treatment of numerous hematological and solid malignancies. Further, the potential utility of HDACI has been extended to non-oncologic applications including auto-immune disorders, inflammation, diseases of the central nervous system and malaria. Given the promise of HDACI, there is growing interest in the potential of dietary compounds that possess HDAC inhibition activity. This review is focused on the identification of and recent findings with HDACI from dietary, medicinal plant and microbial sources. We discuss the mechanisms of action and clinical potential of natural HDACI. |
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Authors:
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Paul V Licciardi; Faith Aa Kwa; Katherine Ververis; Natasha Di Costanzo; Aneta Balcerczyk; Mimi L Tang; Assam El-Osta; Tom Karagiannis |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2012-1-9 |
Journal Detail:
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Title: Antioxidants & redox signaling Volume: - ISSN: 1557-7716 ISO Abbreviation: - Publication Date: 2012 Jan |
Date Detail:
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Created Date: 2012-1-10 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100888899 Medline TA: Antioxid Redox Signal Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Parkville, Victoria, Australia; paul.licciardi@mcri.edu.au. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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