Document Detail

Influence of natural and synthetic histone deacetylase inhibitors on chromatin.
MedLine Citation:
PMID:  22229817     Owner:  NLM     Status:  MEDLINE    
SIGNIFICANCE: Histone deacetylase inhibitors (HDACIs) have emerged as a new class of anticancer therapeutics. The hydroxamic acid, suberoylanilide hydroxamic acid (Vorinostat, Zolinza™), and the cyclic peptide, depsipeptide (Romidepsin, Istodax™), were approved by the U.S. Food and Drug Administration (FDA) for the treatment of cutaneous T-cell lymphoma in 2006 and 2009, respectively. At least 15 HDACIs are currently undergoing clinical trials either alone or in combination with other therapeutic modalities for the treatment of numerous hematological and solid malignancies.
RECENT ADVANCES: The potential utility of HDACIs has been extended to nononcologic applications, including autoimmune disorders, inflammation, diseases of the central nervous system, and malaria.
CRITICAL ISSUES: Given the promise of HDACIs, there is growing interest in the potential of dietary compounds that possess HDAC inhibition activity. This review is focused on the identification of and recent findings with HDACIs from dietary, medicinal plant, and microbial sources. We discuss the mechanisms of action and clinical potential of natural HDACIs.
FUTURE DIRECTIONS: Apart from identification of further HDACI compounds from dietary sources, further research will be aimed at understanding the effects on gene regulation on lifetime exposure to these compounds. Another important issue that requires clarification.
Paul V Licciardi; Faith A A Kwa; Katherine Ververis; Natasha Di Costanzo; Aneta Balcerczyk; Mimi L Tang; Assam El-Osta; Tom C Karagiannis
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review     Date:  2012-02-09
Journal Detail:
Title:  Antioxidants & redox signaling     Volume:  17     ISSN:  1557-7716     ISO Abbreviation:  Antioxid. Redox Signal.     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-05-18     Completed Date:  2013-02-11     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  100888899     Medline TA:  Antioxid Redox Signal     Country:  United States    
Other Details:
Languages:  eng     Pagination:  340-54     Citation Subset:  IM    
Allergy and Immune Disorders, Murdoch Childrens Research Institute, Royal Children's Hospital, Parkville, Victoria, Australia.
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MeSH Terms
Chromatin / drug effects*
Histone Deacetylase Inhibitors / chemical synthesis*,  pharmacology*
Reg. No./Substance:
0/Chromatin; 0/Histone Deacetylase Inhibitors

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