Document Detail

Influence of n-3 fatty acids on blood lipids in normal subjects.
MedLine Citation:
PMID:  2539838     Owner:  NLM     Status:  MEDLINE    
The effects of consuming oils providing alpha-linolenic (ALA), eicosapentaenoic (EPA) and docosahexaenoic (DHA) acids were studied in healthy volunteers. A blunted increase in plasma triglyceride was observed in subjects given a test meal containing fish oil compared with olive oil; cholesterol concentrations were not increased; increases in EPA and DHA were seen in all lipid fractions. In longer term supplementation studies, ALA increased EPA, but not DHA in plasma phospholipids; preformed EPA was more effective. The proportion of EPA in platelet lipids increased in a dose dependent manner. EPA or DHA, but not ALA, decreased plasma triglyceride and VLDL cholesterol concentrations. Supplements containing DHA increased HDL and HDL2 cholesterol and LDL apoB. Total cholesterol and LDL cholesterol concentrations were unaltered.
T A Sanders; A Hinds; C C Pereira
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of internal medicine. Supplement     Volume:  731     ISSN:  0955-7873     ISO Abbreviation:  J Intern Med Suppl     Publication Date:  1989  
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8912975     Medline TA:  J Intern Med Suppl     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  99-104     Citation Subset:  IM    
Department of Food and Nutritional Sciences, King's College London, University of London, UK.
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MeSH Terms
Cholesterol, VLDL / blood
Docosahexaenoic Acids / pharmacology*
Eicosapentaenoic Acid / pharmacology*
Fish Oils / administration & dosage
Lipids / blood*
Triglycerides / blood
Reg. No./Substance:
0/Cholesterol, VLDL; 0/Fish Oils; 0/Lipids; 0/Triglycerides; 1553-41-9/Eicosapentaenoic Acid; 25167-62-8/Docosahexaenoic Acids

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