Document Detail


Influence of mother's intestinal microbiota on gut colonization in the infant.
MedLine Citation:
PMID:  21983067     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim here was to elucidate the mother-infant association in the gut colonization of 1-6 month-old infants and to establish whether probiotics can influence this process. Fecal samples from 80 mother-infant pairs were analyzed at 1 month (mothers and infants) and 6 months (infants) by real-time polymerase chain reaction to assess bacterial numbers. This double-blind placebo-controlled trial involved 2 different probiotic combinations (1. Lactobacillus rhamnosus + Bifidobacterium longum and 2. Lactobacillus paracasei + Bifidobacterium longum) given to the mothers 2 months prior to and 2 months after delivery. Bifidobacterium bifidum colonization in the mothers significantly increased the infants' probability of being colonized by B. bifidum and their bifidobacterial diversity indexes (DI) and the mother-infant similarity indexes (SI) both at 1 and 6 months of age. The counts of Bifidobacterium genus (at 1 month) and Bifidobacterium longum (at 6 months) correlated between mothers and infants. At 6 months, a significant effect of the probiotic intervention was found in the mother-infant association of fecal bifidobacterial counts but not in the colonization frequencies, DI or SI. In conclusion, a clear association between mother and infant was found in gut colonization by bifidobacteria. Maternal colonization by B. bifidum had the most consistent effects on the infant's bifidobacterial microbiota. Maternal probiotic treatment had little effect on this mother-infant association.
Authors:
Minna-Maija Grönlund; Łukasz Grześkowiak; Erika Isolauri; Seppo Salminen
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial; Research Support, Non-U.S. Gov't     Date:  2011-07-01
Journal Detail:
Title:  Gut microbes     Volume:  2     ISSN:  1949-0984     ISO Abbreviation:  Gut Microbes     Publication Date:    2011 Jul-Aug
Date Detail:
Created Date:  2011-10-27     Completed Date:  2012-02-07     Revised Date:  2014-10-09    
Medline Journal Info:
Nlm Unique ID:  101495343     Medline TA:  Gut Microbes     Country:  United States    
Other Details:
Languages:  eng     Pagination:  227-33     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Bacteria / classification,  genetics,  growth & development*,  isolation & purification
Double-Blind Method
Female
Humans
Infant
Intestines / microbiology*
Male
Maternal-Fetal Exchange*
Metagenome*
Pregnancy
Probiotics / administration & dosage*
Prospective Studies

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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