| Influence of modifications of physicochemical and biological properties of haptoglobin. VII. Immunochemical reactivity of haptoglobin with modified tyrosine residues. | |
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MedLine Citation:
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PMID: 412487 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Tyrosine residues in human haptoglobin (Hp) type 2-1 were modified by treatment with various amounts of N-acetylimidazole, iodine or tetranitromethane. Rabbit antisera directed against native Hp, Ac-Hp, 1-Hp and NO2-Hp in cross-reactions by immunoprecipitation showed serologic identify of native Hp and most of the modified derivatives, with the exception of derivatives modified by means of a high excess of N-acetylimidazole, which showed partial identity with remaining preparations, irrespective of the antiserum used. The results indicate that tyrosine residues play no essential role in the immunochemical reactivity of haptoglobin. |
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Authors:
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I Katnik; W Dobryszycka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Archivum immunologiae et therapiae experimentalis Volume: 25 ISSN: 0004-069X ISO Abbreviation: Arch. Immunol. Ther. Exp. (Warsz.) Publication Date: 1977 |
Date Detail:
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Created Date: 1978-01-27 Completed Date: 1978-01-27 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0114365 Medline TA: Arch Immunol Ther Exp (Warsz) Country: POLAND |
Other Details:
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Languages: eng Pagination: 541-8 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acetylation Animals Antigen-Antibody Reactions Cross Reactions Haptoglobins* / immunology, pharmacology* Imidazoles / pharmacology Immunodiffusion Iodine / pharmacology Rabbits Tetranitromethane / pharmacology Tyrosine |
| Chemical | |
Reg. No./Substance:
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0/Haptoglobins; 0/Imidazoles; 509-14-8/Tetranitromethane; 55520-40-6/Tyrosine; 7553-56-2/Iodine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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