Document Detail

Influence of modifications of physicochemical and biological properties of haptoglobin. VII. Immunochemical reactivity of haptoglobin with modified tyrosine residues.
MedLine Citation:
PMID:  412487     Owner:  NLM     Status:  MEDLINE    
Tyrosine residues in human haptoglobin (Hp) type 2-1 were modified by treatment with various amounts of N-acetylimidazole, iodine or tetranitromethane. Rabbit antisera directed against native Hp, Ac-Hp, 1-Hp and NO2-Hp in cross-reactions by immunoprecipitation showed serologic identify of native Hp and most of the modified derivatives, with the exception of derivatives modified by means of a high excess of N-acetylimidazole, which showed partial identity with remaining preparations, irrespective of the antiserum used. The results indicate that tyrosine residues play no essential role in the immunochemical reactivity of haptoglobin.
I Katnik; W Dobryszycka
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Archivum immunologiae et therapiae experimentalis     Volume:  25     ISSN:  0004-069X     ISO Abbreviation:  Arch. Immunol. Ther. Exp. (Warsz.)     Publication Date:  1977  
Date Detail:
Created Date:  1978-01-27     Completed Date:  1978-01-27     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0114365     Medline TA:  Arch Immunol Ther Exp (Warsz)     Country:  POLAND    
Other Details:
Languages:  eng     Pagination:  541-8     Citation Subset:  IM    
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MeSH Terms
Antigen-Antibody Reactions
Cross Reactions
Haptoglobins* / immunology,  pharmacology*
Imidazoles / pharmacology
Iodine / pharmacology
Tetranitromethane / pharmacology
Reg. No./Substance:
0/Haptoglobins; 0/Imidazoles; 509-14-8/Tetranitromethane; 55520-40-6/Tyrosine; 7553-56-2/Iodine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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