| Influence of mitral regurgitation on the response to captopril therapy for congestive heart failure caused by idiopathic dilated cardiomyopathy. | |
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MedLine Citation:
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PMID: 1734651 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To assess the influence of mitral regurgitation (MR) on the response to captopril therapy for congestive heart failure (CHF), 30 patients with idiopathic dilated cardiomyopathy in New York Heart Association functional class III were studied. Left ventricular end-diastolic diameter and stroke volume were measured by Doppler echocardiography, and exercise tolerance by exercise testing before and at 1, 3 and 12 months after treatment. Patients were classified into 2 groups: those with (n = 14) and those without (n = 16) MR. No significant differences were observed between the 2 groups in pretreatment studies. Exercise tolerance increased significantly in the group with MR (p less than 0.001) during the year of follow-up, from 514 +/- 193 seconds at baseline study to 671 +/- 178 seconds (p less than 0.0005) at 1 month, 688 +/- 127 seconds (p less than 0.0005) at 3 months and 690 +/- 108 seconds (p less than 0.01) at 12 months. The group without MR had no significant changes. Stroke volume increased significantly only in the MR group during follow-up (p less than 0.01), changing from 43 +/- 9 ml at baseline study to 52 +/- 11 ml (p less than 0.01) at 1 and 49 +/- 11 ml (p less than 0.01) at 3 months. At 12 months the increase was not statistically significant. Left ventricular end-diastolic diameter decreased more in the group with than without MR, although the differences were not significant. Thus, the presence of dynamic MR appears to be an important factor in the therapeutic response to captopril therapy for CHF. |
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Authors:
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A Evangelista-Masip; J Bruguera-Cortada; R Serrat-Serradell; A Robles-Castro; E Galve-Basilio; M Alijarde-Guimera; J Soler-Soler |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of cardiology Volume: 69 ISSN: 0002-9149 ISO Abbreviation: Am. J. Cardiol. Publication Date: 1992 Feb |
Date Detail:
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Created Date: 1992-03-02 Completed Date: 1992-03-02 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0207277 Medline TA: Am J Cardiol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 373-6 Citation Subset: AIM; IM |
Affiliation:
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Servei de Cardiologia, Hospital General Universitari Vall d'Hebrón, Barcelona, Spain. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Analysis of Variance Captopril / therapeutic use* Cardiomyopathy, Dilated / complications, drug therapy*, physiopathology Echocardiography, Doppler Exercise Test Humans Middle Aged Mitral Valve Insufficiency / complications, physiopathology* Stroke Volume / drug effects Ventricular Function, Left / drug effects |
| Chemical | |
Reg. No./Substance:
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62571-86-2/Captopril |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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