| Influence of milrinone and norepinephrine on blood flow in canine internal mammary artery grafts. | |
| | |
MedLine Citation:
|
PMID: 8633943 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: Vasoactive agents are frequently needed in patients undergoing myocardial revascularization. The purpose of this study was to examine blood flow in the internal mammary artery (IMA) during infusion of drugs that are commonly used after myocardial revascularization. METHODS: A canine right heart bypass preparation allowed precise control of cardiac output and blood pressure, which were maintained constant during drug infusion to isolate the effect of the drug on the IMA conduit. The IMA was anastomosed to a ligated left anterior descending coronary artery. Electromagnetic flow probes measured IMA graft flow. RESULTS: Norepinephrine (0.1 microgram.kg-1.min-1) alone and when combined with phentolamine (8:5 ratio) did not alter IMA flow. Milrinone increased IMA flow 33% +/- 9%, from 37 +/- 7 to 49 +/- 10 mL/min. All hemodynamic variables were unchanged. CONCLUSIONS: The results suggest that: (1) norepinephrine did not have a deleterious effect on IMA flow and (2) milrinone may be a useful drug in patients undergoing myocardial revascularization by increasing IMA blood flow. |
| | |
Authors:
|
R Gitter; J M Anderson; G K Jett |
Related Documents
:
|
16225153 - Numerical study on the pulsatile flow characteristics of proximal anastomotic models. 2054653 - Cerebrovascular responsiveness to hypercapnia in intracerebral tissue transplants. 12177153 - Post-prandial blood flow to the gastrointestinal tract is not compromised during hypoxi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: The Annals of thoracic surgery Volume: 61 ISSN: 0003-4975 ISO Abbreviation: Ann. Thorac. Surg. Publication Date: 1996 May |
Date Detail:
|
Created Date: 1996-07-02 Completed Date: 1996-07-02 Revised Date: 2010-03-24 |
Medline Journal Info:
|
Nlm Unique ID: 15030100R Medline TA: Ann Thorac Surg Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 1367-71 Citation Subset: AIM; IM |
Affiliation:
|
Department of Cardiothoracic Surgery, Baylor University Medical Center, Dallas 75218, Texas. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Animals Coronary Circulation / drug effects* Dogs Heart Bypass, Right Hemodynamics / drug effects Internal Mammary-Coronary Artery Anastomosis* Milrinone Norepinephrine / pharmacology* Pyridones / pharmacology* Regional Blood Flow / drug effects Vasoconstrictor Agents / pharmacology* Vasodilator Agents / pharmacology* |
| Chemical | |
Reg. No./Substance:
|
0/Pyridones; 0/Vasoconstrictor Agents; 0/Vasodilator Agents; 51-41-2/Norepinephrine; 78415-72-2/Milrinone |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Heparin-coated circuits and aprotinin prime for coronary artery bypass grafting.
Next Document: Postoperative aprotinin: effect on blood loss and transfusion requirements in cardiac operations.