| Influence of methyltestosterone postmenopausal therapy on plasma lipids, inflammatory factors, glucose metabolism and visceral fat: a randomized study. | |
| | |
MedLine Citation:
|
PMID: 16382002 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
BACKGROUND: There has been a growing interest in treating postmenopausal women with androgens. However, hyperandrogenemia in females has been associated with increased risk of cardiovascular disease. OBJECTIVE: We aimed to assess the effects of androgen replacement on cardiovascular risk factors. DESIGN: Thirty-seven postmenopausal women aged 42-62 years that had undergone hysterectomy were prospectively enrolled in a double-blind protocol to receive, for 12 months, percutaneous estradiol (E2) (1 mg/day) combined with either methyltestosterone (MT) (1.25 mg/day) or placebo. METHODS: Along with treatment, we evaluated serum E2, testosterone, sex hormone-binding globulin (SHBG), free androgen index, lipids, fibrinogen, and C-reactive protein; glucose tolerance; insulin resistance; blood pressure; body-mass index; and visceral and subcutaneous abdominal fat mass as assessed by computed tomography. RESULTS: A significant reduction in SHBG (P < 0.001) and increase in free testosterone index (P < 0.05; Repeated measures analysis of variance) were seen in the MT group. Total cholesterol, triglycerides, fibrinogen, and systolic and diastolic blood pressure were significantly lowered to a similar extent by both regimens, but high-density lipoprotein cholesterol decreased only in the androgen group. MT-treated women showed a modest rise in body weight and gained visceral fat mass relative to the other group (P < 0.05), but there were no significant detrimental effects on fasting insulin levels and insulin resistance. CONCLUSION: This study suggests that the combination of low-dose oral MT and percutaneous E2, for 1 year, does not result in expressive increase of cardiovascular risk factors. This regimen can be recommended for symptomatic postmenopausal women, although it seems prudent to perform baseline and follow-up lipid profile and assessment of body composition, especially in those at high risk of cardiovascular disease. |
| | |
Authors:
|
Lenora M Camarate S M Leão; Mônica Peres C Duarte; Dalva Margareth B Silva; Paulo Roberto V Bahia; Cláudia Medina Coeli; Maria Lucia Fleiuss de Farias |
Publication Detail:
|
Type: Journal Article; Randomized Controlled Trial |
Journal Detail:
|
Title: European journal of endocrinology / European Federation of Endocrine Societies Volume: 154 ISSN: 0804-4643 ISO Abbreviation: Eur. J. Endocrinol. Publication Date: 2006 Jan |
Date Detail:
|
Created Date: 2005-12-29 Completed Date: 2006-03-10 Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 9423848 Medline TA: Eur J Endocrinol Country: England |
Other Details:
|
Languages: eng Pagination: 131-9 Citation Subset: IM |
Affiliation:
|
Service of Endocrinology, University Hospital Clementino Fraga Filho, Federal University of Rio de Janeiro, Brazil. lenora_leao@yahoo.com.br |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Abdominal Fat
/
anatomy & histology,
drug effects* Acute-Phase Proteins / metabolism* Administration, Oral Adult Blood Glucose / metabolism* Blood Pressure / drug effects C-Reactive Protein / metabolism Estrogen Replacement Therapy* Female Fibrinogen / metabolism Humans Hysterectomy Lipids / blood* Methyltestosterone / administration & dosage, therapeutic use* Middle Aged Ovariectomy Postmenopause* Sex Hormone-Binding Globulin / metabolism |
| Chemical | |
Reg. No./Substance:
|
0/Acute-Phase Proteins; 0/Blood Glucose; 0/Lipids; 0/Sex Hormone-Binding Globulin; 58-18-4/Methyltestosterone; 9001-32-5/Fibrinogen; 9007-41-4/C-Reactive Protein |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Postnatal penile length and growth rate correlate to serum testosterone levels: a longitudinal study...
Next Document: Metabolic syndrome in polycystic ovary syndrome (PCOS): lower prevalence in southern Italy than in t...