Document Detail

Influence of the method of intracavernous injection on penile rigidity: a possible pharmacokinetic explanation.
MedLine Citation:
PMID:  9037289     Owner:  NLM     Status:  MEDLINE    
OBJECTIVES: To study whether the method of intracavernous injection of vasodilators has an effect on the clinical outcome and to explain the mechanism of possible influence. METHODS: In an open clinical study, penile rigidity after bolus injection was compared with rigidity after slow injection in 52 self-injecting, impotent patients. In 35 volunteers, venous plasma levels of intracavernosally injected drugs were followed under different injection conditions: slow injection of undiluted drug, slow injection of diluted drug, bolus injection, use of a tourniquet, or slow injection followed by squeeze of the corpora. RESULTS: Of the 52 patients, 28 reported better penile rigidity after a bolus injection than after slow injection of vasodilators. The other 24 reported no difference in rigidity. Systemic side effects did not occur, but 4 patients reported local pain after bolus injection. In the 35 volunteers, the lowest plasma levels were observed when a tourniquet was used or when a bolus injection was performed; the quickest transfer was observed after a slow injection of a low volume of the drug. CONCLUSIONS: Better rigidity was observed after bolus injection in a majority of the patients using the same dose of vasodilators. This could be due to the pharmacokinetic phenomenon of a slower drug transfer to the systemic circulatory system after a bolus than after a slow injection.
J M de Meyer; W Oosterlinck
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Urology     Volume:  49     ISSN:  0090-4295     ISO Abbreviation:  Urology     Publication Date:  1997 Feb 
Date Detail:
Created Date:  1997-03-14     Completed Date:  1997-03-14     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0366151     Medline TA:  Urology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  248-52     Citation Subset:  IM    
Department of Urology, University Hospital, Ghent, Belgium.
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MeSH Terms
Erectile Dysfunction / drug therapy*
Injections / methods
Middle Aged
Penile Erection / drug effects*
Vasodilator Agents / administration & dosage*,  pharmacokinetics
Reg. No./Substance:
0/Vasodilator Agents

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