| Influence of metabolic fuel on the 13C/12C ratio of breath CO2. | |
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MedLine Citation:
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PMID: 6441607 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Natural differences in 13C/12C ratios of various metabolic fuels can produce systematic changes in the 13C/12C ratio of breath CO2, and therefore introduce errors into 13CO2 breath tests. To gain insight into the potential problem, we compared 13C/12C ratios of plasma macronutrients to those of breath CO2 under conditions that should alter the percentages of carbohydrate and lipid being oxidized. In rats, 48 h of starvation decreased the 13C/12C ratio of breath CO2 by 3.5%. At this time the 13C/12C ratio of breath CO2 was very similar to that of plasma lipids. In humans, 30 min of heavy exercise increased the breath 13CO2/12CO2 ratio by 1.3%. These changes in breath 13C/12C ratios could be predicted from 13C/12C ratios of plasma macronutrients and the percentage of carbon dioxide derived from each macronutrient, but only when compared within the same populations. For example, the 13C/12C ratios of plasma macronutrients of residents of Chicago, Illinois (USA) and Tokyo (Japan) differed by 1-3%. An empirical correction of 13CO2 breath test data is recommended when breath tests are run under conditions that will change metabolic fuel utilization. |
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Authors:
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D A Schoeller; C Brown; K Nakamura; A Nakagawa; R S Mazzeo; G A Brooks; T F Budinger |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Biomedical mass spectrometry Volume: 11 ISSN: 0306-042X ISO Abbreviation: Biomed. Mass Spectrom. Publication Date: 1984 Nov |
Date Detail:
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Created Date: 1985-04-11 Completed Date: 1985-04-11 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 0430246 Medline TA: Biomed Mass Spectrom Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 557-61 Citation Subset: IM; S |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Animals Blood Glucose / analysis Blood Proteins / analysis Breath Tests* Carbon Dioxide / analysis* Carbon Isotopes / analysis Energy Metabolism* Humans Lipids / blood Male Physical Exertion Pulmonary Gas Exchange* Rats Starvation / metabolism |
| Grant Support | |
ID/Acronym/Agency:
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AM-19577/AM/NIADDK NIH HHS; AM-26678/AM/NIADDK NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Blood Glucose; 0/Blood Proteins; 0/Carbon Isotopes; 0/Lipids; 124-38-9/Carbon Dioxide |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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