Document Detail


Influence of the mesenchymal cell source on oral epithelial development.
MedLine Citation:
PMID:  21548135     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The extent of the influence of mesenchymal tissue on epithelial development is still debated, and elucidation of epithelial-mesenchymal interactions should be of relevance for controlling normal as well as pathological growth and development. The aim of the present study was to elucidate the influence of the mesenchymal cell type on oral mucosa epithelial development in vitro, using tissue-engineering principles, by including three different sources for mesenchymal cell type, viz. oral mucosa, skin and cornea, each of them presenting a distinct type of epithelium in situ. We investigated epithelial-mesenchymal interactions, considering both morphological criteria and protein expression (filaggrin, keratin 10, keratin 12, keratin 13 and laminin 5). The results of the histology, immunohistochemistry and transmission electron microscopy of the three types of tissue-engineered constructs composed of mesenchymal cells of different sources (oral, dermal and corneal fibroblasts) and of the same oral epithelial cells showed that the mesenchymal cell source had a significant influence on the thickness and ultrastructure of the epithelium, but not on the differentiation of oral epithelial cells, which might be an intrinsic property of these cells due to their genetic programming. Copyright © 2011 John Wiley & Sons, Ltd.
Authors:
Beste Kinikoglu; Marie Rose Rovere; Marek Haftek; Vasif Hasirci; Odile Damour
Related Documents :
8130735 - Mannose dependent tightening of the rat ependymal cell barrier. in vivo and in vitro st...
16099865 - Characterization of a novel rat epididymal cell line to study epididymal function.
7105145 - The glomus cell of the carotid labyrinth of xenopus laevis.
19126675 - Connexin mutation that causes dominant congenital cataracts inhibits gap junctions, but...
22453795 - Differential response of three cell types to dual stress of nitric oxide and radiation.
22299045 - Defining the cellular environment in the organ of corti following extensive hair cell l...
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-5-5
Journal Detail:
Title:  Journal of tissue engineering and regenerative medicine     Volume:  -     ISSN:  1932-7005     ISO Abbreviation:  -     Publication Date:  2011 May 
Date Detail:
Created Date:  2011-5-6     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101308490     Medline TA:  J Tissue Eng Regen Med     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons, Ltd.
Affiliation:
Banque de Tissus et Cellules, Hospices Civils de Lyon, 69437 Lyon, France; METU, BIOMAT, Department of Biotechnology, 06531 Ankara, Turkey.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  In vitro study of chondrocyte redifferentiation with lentiviral vector-mediated transgenic TGF-?3 an...
Next Document:  Bone morphogenetic protein-2 in biodegradable gelatin and ?-tricalcium phosphate sponges enhances th...