Document Detail

Influence of meperidine on fetal movements and heart rate beat-to-beat variability in the active phase of labor.
MedLine Citation:
PMID:  3382477     Owner:  NLM     Status:  MEDLINE    
Eleven parturients were studied in the active phase of labor. Fetal movements, fetal heart rate, and short-term beat-to-beat variability as well as uterine contractions were evaluated for two 40-minute recording periods before and after maternal intravenous administration of 50 mg meperidine. Meperidine depressed fetal activity and increased the duration and frequency of uterine contractions. Fetal movements were significantly reduced from 156 to 60 and their relative duration from 8.6 +/- 6.0% to 2.4 +/- 2.6% (p less than 0.01). The short-term fetal heart rate beat-to-beat variability was reduced at the baseline period 5.22 +/- 1.02 versus 4.62 +/- 1.47 (p less than 0.05) but not during uterine contractions or fetal movements. The frequency of uterine contractions increased from 3.1 +/- 0.8 to 3.7 +/- 0.7 per 10 minutes (p less than 0.01), and their relative duration from 35.3 +/- 6.9% to 40.1 +/- 5.9% (p less than 0.05).
E Z Zimmer; M Y Divon; A Vadasz
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  5     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1988 Jul 
Date Detail:
Created Date:  1988-08-09     Completed Date:  1988-08-09     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  197-200     Citation Subset:  IM    
Department of Obstetrics and Gynecology B, Rambam Medical Center, Haifa, Israel.
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MeSH Terms
Drug Evaluation
Fetal Movement / drug effects*
Heart Rate, Fetal / drug effects*
Labor, Obstetric / drug effects*
Meperidine / pharmacology*
Uterine Contraction / drug effects
Reg. No./Substance:

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