Document Detail


Influence of the menstrual cycle on proenkephalin peptide F responses to maximal cycle exercise.
MedLine Citation:
PMID:  16408233     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Proenkephalin peptide F [107-140] is an enkephalin-containing peptide found predominantly within the adrenal medulla and is co-packaged with epinephrine within adrenal medullary chromaffin granules. Peptide F has been shown to have the classic opioid analgesia effects along with immune cell interactions. This is only the second peptide F study in women, and in it we compare the responses of peptide F to a maximal cycle exercise test and recovery values over the follicular and luteal phases of the menstrual cycle. Eight untrained (directly documented in this study) women who were eumenorrheic performed a progressive maximal exercise test to volitional exhaustion on a cycle ergometer, once during the follicular phase, and once during the luteal phases of the menstrual cycle. Blood was obtained pre-exercise, immediately post-exercise and at 0, 15, and 30 min into recovery. Typical exercise changes in response to the cycle tests were observed with blood lactate increases that remained elevated 30 min into recovery. No significant exercise-induced elevations were observed for peptide F concentrations with exercise nor were any differences observed between the two menstrual phases. Thus, the effects of the menstrual cycle on peptide F concentrations appear to be minimal under the conditions of this investigation. With high concentrations of peptide F observed at rest (approx. 0.2-0.3 pmol ml(-1)) pre-exercise arousal mechanisms may have obviated any exercise-induced response. In addition, inhibition via elevated epinephrine may have inhibited any post-exercise increases and finally adrenal medullary capacity for circulatory concentrations of peptide F may have been reached in such untrained women. Pre-exercise arousal mechanisms potentially related to analgesia may also be involved to prepare untrained women for the stress of maximal exercise.
Authors:
William J Kraemer; Sang K Kim; Jill A Bush; Bradley C Nindl; Jeff S Volek; Barry A Spiering; Disa L Hatfield; Maren S Fragala; Margo Putukian; Wayne J Sebastianelli
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Publication Detail:
Type:  Journal Article     Date:  2006-01-12
Journal Detail:
Title:  European journal of applied physiology     Volume:  96     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2006 Mar 
Date Detail:
Created Date:  2006-03-14     Completed Date:  2006-06-29     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  581-6     Citation Subset:  IM    
Affiliation:
Human Performance Laboratory, Department of Kinesiology, University of Connecticut, Storrs, CT, 06269, USA. William.Kraemer@uconn.edu
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adrenal Medulla / physiology*
Adult
Enkephalin, Methionine / analogs & derivatives*,  blood
Estradiol / blood
Exercise / physiology*
Exercise Test
Female
Follicular Phase / physiology*
Heart Rate / physiology
Humans
Lactic Acid / blood
Luteal Phase / physiology*
Plasma Volume / physiology
Progesterone / blood
Protein Precursors / blood*
Chemical
Reg. No./Substance:
0/Protein Precursors; 50-21-5/Lactic Acid; 50-28-2/Estradiol; 57-83-0/Progesterone; 58569-55-4/Enkephalin, Methionine; 75718-92-2/peptide F

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