Document Detail


Influence of menstrual cycle phase on muscle metaboreflex control of cardiac baroreflex sensitivity, heart rate and blood pressure in humans.
MedLine Citation:
PMID:  22613743     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
We sought to determine whether menstrual cycle phase influences muscle metaboreflex control of spontaneous cardiac baroreflex sensitivity (cBRS), blood pressure (BP) and heart rate (HR). Twenty three young women not taking oral contraceptives were studied during the early (EF; low oestrogen, low progesterone) and late follicular (LF; high oestrogen, low progesterone) menstrual phases. Protocol 1, comprised of leg cycling at low (21±2 Watts) and moderate workloads (71±3 Watts), under free-flow conditions and with partial flow-restriction (bilateral thigh cuff inflation at 100 mmHg) to activate the muscle metaboreflex. Protocol 2, comprised of rhythmic handgrip exercise with incremental upper arm cuff inflation (0, 80, 100 and 120 mmHg) to elicit graded metaboreflex activation. Both protocols were followed by post-exercise ischemia (PEI). Leg cycling decreased cBRS (EF 20±5, 6±1 and 1±0.1; LF 19±3, 6±0.4, 1±0.1 ms·mmHg(-1) during rest, low and moderate intensity leg cycling) and increased HR in an intensity dependent manner, while BP remained unchanged. Partial flow-restriction during leg cycling decreased cBRS, and increased HR and BP. During PEI, HR and BP remained elevated, while cBRS remained suppressed (EF 4.2±0.6; LF 4.7±0.5 ms·mmHg(-1); P<0.05 vs. rest). cBRS was unchanged during handgrip with and without partial flow-restriction and PEI. No differences in cBRS, HR or BP responses were observed between EF and LF at any time during either protocol. These data indicate that endogenous fluctuations in oestrogen between the EF and LF phases of the menstrual cycle do not influence muscle metaboreflex control of cBRS, BP or HR in young women.
Authors:
Doreen Hartwich; Sarah Aldred; James P Fisher
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-21
Journal Detail:
Title:  Experimental physiology     Volume:  -     ISSN:  1469-445X     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9002940     Medline TA:  Exp Physiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
University of Birmingham.
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