Document Detail


Influence of mechanical ventilation on blood lactate in patients with acute respiratory failure.
MedLine Citation:
PMID:  9803328     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVES: To determine whether mechanical ventilation (MV) may affect blood lactate concentration in patients with acute respiratory failure. DESIGN: Prospective observational study with follow-up to hospital discharge. SETTING: A 17-bed medical and coronary intensive care unit in a 650-bed general hospital. PATIENTS: 55 adult patients mechanically ventilated for acute respiratory failure between May 1996 and April 1997 were recruited. MEASUREMENTS AND RESULTS: Arterial blood samples for determination of plasma lactate and blood gas analysis were taken just before tracheal intubation on spontaneous breathing, and 20 and 60 min after the initiation of controlled MV. Cuff systemic arterial pressure was measured before tracheal intubation and every 10 min during the first h of MV. Hyperlactatemia (arterial blood lactate > or = 2 mmol/l) was present in 21 of the 55 patients studied. After 20 min of MV, there was a decrease in blood lactate from 4.74 +/- 1.78 to 3.07 +/- 1.69 mmol/l (p < 0.01); 40 min later there was a further decrease to 2.63 +/- 1.35 mmol/l (p < 0.05). The decrease in blood lactate was also observed in those patients who after starting MV developed systemic arterial hypotension (p < 0.01). In patients with a normal lactate concentration at the entry to the study, lactate remained the same after 60 min on MV (NS). CONCLUSIONS: Controlled MV decreases substantially the severity of hyperlactatemia in patients with acute respiratory failure, and any adverse circulatory effects of MV do not alter this beneficial outcome.
Authors:
A Gil; F Carrizosa; A Herrero; J Martin; J González; A Jareño; J Rivero
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  24     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1998 Sep 
Date Detail:
Created Date:  1999-01-19     Completed Date:  1999-01-19     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  924-30     Citation Subset:  IM    
Affiliation:
Intensive Care Unit, Hospital of Jerez, C(a) Circunvalacion sn, Jerez de la Frontera, Spain. anselgil@ctv.es
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Gas Analysis
Female
Follow-Up Studies
Humans
Lactic Acid / blood*
Male
Middle Aged
Prospective Studies
Respiration, Artificial*
Respiratory Distress Syndrome, Adult / blood*,  therapy
Time Factors
Chemical
Reg. No./Substance:
50-21-5/Lactic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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