| Influence of maximal ergometric exercise on endothelin concentrations in relation to molecular markers of the hemostatic system. | |
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MedLine Citation:
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PMID: 8743188 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of moderate 30 min cycle ergometer exercise (aerobic metabolism; 0.85-3.71 mmol.1(-1) lactate) followed by short-term exercise at maximal capacity (anaerobic metabolism; 5.09 to 17.75 mmol.1(-1) lactate) on endothelin (ET) and hemostatic variables (tissue plasminogen activator [t-PA] antigen, prothrombin fragments [F1,2], thrombin-antithrombin III complex [TAT], prothrombin time and partial thromboplastin time) were investigated in 15 male healthy subjects of varying fitness levels. Endothelin was measured twice before and immediately after maximal cycle exercise. The results show an increase in endothelin concentration [10.0 pg.ml-1 (baseline) + 6.1 pg.ml-1 (increase post exercise)]. ET did not increase under control conditions. Moderate 30 min exercise caused an increase in t-PA antigen concentration (3.66 + 3.15 ng.ml-1) and short-term maximal exercise produced a markedly higher elevation in this variable (+10.6 ng.ml-1). F1,2 increased (810 + 40 pmol.l-1) under moderate and by 150 pmol.l-1 under anaerobic exercise. TAT increased only at maximal exercise levels (1.01 + 0.32 ng.l-1). No changes were found in any of these variables under control conditions. No correlation of endothelin and the hemostatic variables was found. It is concluded that endothelin and hemostatic markers increase independently during moderate and maximal exercise. |
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Authors:
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L Röcker; M Möckel; K P Westpfahl; H C Gunga |
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Publication Detail:
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Type: Clinical Trial; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: Thrombosis and haemostasis Volume: 75 ISSN: 0340-6245 ISO Abbreviation: Thromb. Haemost. Publication Date: 1996 Apr |
Date Detail:
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Created Date: 1996-11-05 Completed Date: 1996-11-05 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 7608063 Medline TA: Thromb Haemost Country: GERMANY |
Other Details:
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Languages: eng Pagination: 612-6 Citation Subset: IM |
Affiliation:
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Department of Physiology, Free University, Berlin, Germany. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Biological Markers / blood Endothelins / blood* Exercise / physiology* Hemostasis / physiology* Humans Male Reference Values |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Endothelins |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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