Document Detail

Influence of maximal ergometric exercise on endothelin concentrations in relation to molecular markers of the hemostatic system.
MedLine Citation:
PMID:  8743188     Owner:  NLM     Status:  MEDLINE    
The effects of moderate 30 min cycle ergometer exercise (aerobic metabolism; 0.85-3.71 mmol.1(-1) lactate) followed by short-term exercise at maximal capacity (anaerobic metabolism; 5.09 to 17.75 mmol.1(-1) lactate) on endothelin (ET) and hemostatic variables (tissue plasminogen activator [t-PA] antigen, prothrombin fragments [F1,2], thrombin-antithrombin III complex [TAT], prothrombin time and partial thromboplastin time) were investigated in 15 male healthy subjects of varying fitness levels. Endothelin was measured twice before and immediately after maximal cycle exercise. The results show an increase in endothelin concentration [10.0 (baseline) + 6.1 (increase post exercise)]. ET did not increase under control conditions. Moderate 30 min exercise caused an increase in t-PA antigen concentration (3.66 + 3.15 and short-term maximal exercise produced a markedly higher elevation in this variable (+10.6 F1,2 increased (810 + 40 pmol.l-1) under moderate and by 150 pmol.l-1 under anaerobic exercise. TAT increased only at maximal exercise levels (1.01 + 0.32 ng.l-1). No changes were found in any of these variables under control conditions. No correlation of endothelin and the hemostatic variables was found. It is concluded that endothelin and hemostatic markers increase independently during moderate and maximal exercise.
L Röcker; M Möckel; K P Westpfahl; H C Gunga
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Thrombosis and haemostasis     Volume:  75     ISSN:  0340-6245     ISO Abbreviation:  Thromb. Haemost.     Publication Date:  1996 Apr 
Date Detail:
Created Date:  1996-11-05     Completed Date:  1996-11-05     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7608063     Medline TA:  Thromb Haemost     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  612-6     Citation Subset:  IM    
Department of Physiology, Free University, Berlin, Germany.
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MeSH Terms
Biological Markers / blood
Endothelins / blood*
Exercise / physiology*
Hemostasis / physiology*
Reference Values
Reg. No./Substance:
0/Biological Markers; 0/Endothelins

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