Document Detail


Influence of maternal smoking on neonatal aortic intima-media thickness, serum IGF-I and IGFBP-3 levels.
MedLine Citation:
PMID:  17203279     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Epidemiological studies have reported associations between a range of cardiovascular risk factors such as smoking and intima-media thickness (IMT). Some reports indicate that the maternal tobacco smoking causes disturbances of the endocrine status of the foetus. There are several potential mechanisms by which insulin-like growth factor I (IGF-I) could modify atherosclerotic processes either locally or in a systemic manner. The aim of this study was to investigate the influence of maternal smoking on neonatal aortic IMT (aIMT), serum IGF-I and IGF-binding protein-3 (IGFBP-3) levels. Aortic intima-media thickness was measured in 28 neonates whose mothers smoked during the pregnancy and 28 control neonates. Mean and weight-adjusted aIMT were significantly greater in the neonates whose mothers smoked (0.455 +/- 0.009 mm and 0.151 +/- 0.005 mm/kg, respectively) than in controls (0.403 +/- 0.029 mm and 0.118 +/- 0.014 mm/kg, respectively). Birth-weight of newborns whose mothers smoked was less than that of the controls. The decreases in serum IGF-I and IGFBP-3 observed in the infants whose mothers smoked were non-significant. Mean aIMT was negatively associated with birth-weight and IGF-I level. In conclusion, neonates whose mothers smoked have significantly increased aIMT. It might play a role in the pathogenesis of atherosclerosis in adult life.
Authors:
Tamer Gunes; Esad Koklu; Ali Yikilmaz; Mehmet Adnan Ozturk; Mustafa Akcakus; Selim Kurtoglu; Abdulhakim Coskun; Selmin Koklu
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-01-04
Journal Detail:
Title:  European journal of pediatrics     Volume:  166     ISSN:  0340-6199     ISO Abbreviation:  Eur. J. Pediatr.     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-08-27     Completed Date:  2008-11-18     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7603873     Medline TA:  Eur J Pediatr     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  1039-44     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, Division of Neonatology,, School of Medicine, Erciyes University, Kayseri, Turkey.
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MeSH Terms
Descriptor/Qualifier:
Adult
Aorta / anatomy & histology*,  drug effects,  ultrasonography
Birth Weight
Female
Humans
Infant, Newborn
Insulin-Like Growth Factor Binding Protein 3 / blood*
Insulin-Like Growth Factor I / metabolism*
Logistic Models
Male
Maternal Exposure / adverse effects
Pregnancy
Smoking / adverse effects*,  blood
Tunica Intima / anatomy & histology,  ultrasonography
Tunica Media / anatomy & histology,  ultrasonography
Chemical
Reg. No./Substance:
0/Insulin-Like Growth Factor Binding Protein 3; 67763-96-6/Insulin-Like Growth Factor I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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