Document Detail

Influence of maternal nutritional status on vascular function in the offspring.
MedLine Citation:
PMID:  21418376     Owner:  NLM     Status:  Publisher    
Sub-optimal maternal nutritional status has been implicated in the development of cardiovascular risk in the child. Initially inferred from studies of low birthweight children, investigations in cohorts of women subjected to famine, provide direct evidence for an independent influence of the mother's diet on the cardiovascular health of her child. Animal studies from rodents and sheep have shown associations between maternal undernutrition and raised blood pressure, as well as abnormalities in resistance artery function, particularly in endothelium dependent responses. Early life exposure to the influences of maternal over nutritional states eg obesity and excessive gestational weight gain has also been associated with markers of cardiovascular risk in man, and animal models have showed raised blood pressure and endothelial dysfunction in offspring of diet-induced obese dams. Increased sympathetic tone is commonly associated with hypertension in animal models of both under and over nutritional states. This and several other similarities may indicate commonality of mechanism and could reflect supra-normal nutritional status in post-natal life in both conditions.
Lucilla Poston
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-2-5
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  -     ISSN:  1549-8719     ISO Abbreviation:  -     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 John Wiley & Sons Ltd.
Division of Women's Health King's College London.
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