Document Detail

Influence of maternal lipid profile on placental protein expression of LDLr and SR-BI.
MedLine Citation:
PMID:  17531953     Owner:  NLM     Status:  MEDLINE    
Maternal hyperlipidemia is a characteristic feature during pregnancy, it has been reported that modification of the maternal lipid profile can induce disturbance during pregnancy. In this study, we evaluated the impact of maternal lipid profile on the placental protein expression of two major receptors in cholesterol metabolism, the low density lipoprotein receptor (LDLr) and the scavenger receptor type B1 (SR-B1). We demonstrate an increase in the level of maternal total circulating cholesterol leads to a significant decrease in the level of the LDLr protein expression, while the level of the SR-BI expression remains unchanged. A similar change, for LDLr, is observed in association with the maternal pre-pregnancy body mass index and weight gain. Our data suggest that the LDLr plays a role in regulating cholesterol delivered to the baby from the placenta.
M Ethier-Chiasson; A Duchesne; J-C Forest; Y Giguère; A Masse; C Mounier; J Lafond
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-05-15
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  359     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-05     Completed Date:  2007-08-09     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  United States    
Other Details:
Languages:  eng     Pagination:  8-14     Citation Subset:  IM    
Laboratoire de Physiologie Materno-Foetale, Département des Sciences Biologiques, Université du Québec à Montréal, C.P. 8888, Succursale Centre-ville, Montréal, Que., Canada H3C 3P8.
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MeSH Terms
Body Mass Index
Gene Expression / physiology
Lipid Metabolism / physiology*
Maternal-Fetal Exchange / physiology*
Placenta / metabolism*
Receptors, LDL / metabolism*
Scavenger Receptors, Class B / metabolism*
Reg. No./Substance:
0/Receptors, LDL; 0/SCARB1 protein, human; 0/Scavenger Receptors, Class B

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