Document Detail


Influence of maternal factors on cord and neonatal plasma micronutrient levels.
MedLine Citation:
PMID:  8442795     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of gestational length, maternal prenatal supplement and maternal levels on umbilical cord and neonatal plasma selenium, alpha-tocopherol, and retinol were studied and appropriate reference intervals for ongoing studies of gestational and perinatal micronutrient requirements were derived. We measured retinol, alpha-tocopherol (total and alpha-tocopherol:cholesterol ratio), selenium, and glutathione peroxidase in 160 umbilical cord samples and 58 paired maternal and neonatal samples collected on the third postpartum day. Selenium and glutathione peroxidase were also measured in 25 paired umbilical artery and vein samples. The strongest correlation with gestational age and birthweight was found for the cord blood variables, whereas levels in maternal blood were not related to either gestation or weight. Neonatal values were significantly lower than maternal for selenium (0.96 [0.25] compared with 1.56 [0.27] mumol/liter), retinol (0.54 [0.19] and 1.26 [0.45] mumol/liter), alpha-tocopherol (11.5 [3.63] and 32.4 [9.20] mumol/liter), and glutathione peroxidase (446 [174] and 873 [176] U/liter) but not for the ratio of alpha-tocopherol:cholesterol (5.0 compared with 6.0). Maternal use of tocopherol and retinol supplements did not significantly affect blood concentrations. Maternal plasma selenium levels at term were about 60% of nonpregnant adult females. Selenium concentration and glutathione peroxidase activity did not differ between paired umbilical cord arterial and venous samples. Selenium, retinol, and glutathione peroxidase differed between infants born before or after 37 weeks' gestation.
Authors:
P J Dison; G Lockitch; A C Halstead; M R Pendray; A Macnab; B K Wittmann
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  American journal of perinatology     Volume:  10     ISSN:  0735-1631     ISO Abbreviation:  Am J Perinatol     Publication Date:  1993 Jan 
Date Detail:
Created Date:  1993-04-08     Completed Date:  1993-04-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8405212     Medline TA:  Am J Perinatol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  30-5     Citation Subset:  IM    
Affiliation:
Department of Pathology, University of British Columbia, Vancouver, Canada.
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MeSH Terms
Descriptor/Qualifier:
Birth Weight
Female
Fetal Blood / chemistry*
Gestational Age
Glutathione Peroxidase / blood
Humans
Infant, Newborn / blood*
Pregnancy / blood*
Reference Values
Selenium / blood*
Vitamin A / blood*
Vitamin E / blood*
Chemical
Reg. No./Substance:
11103-57-4/Vitamin A; 1406-18-4/Vitamin E; 7782-49-2/Selenium; EC 1.11.1.9/Glutathione Peroxidase

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