| Influence of maternal CD4 levels on the predictive value of virus load over mother-to-child transmission of human immunodeficiency virus type 1 (HIV-1). Study Group for Vertical Transmission. | |
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MedLine Citation:
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PMID: 10223547 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Forty-four anti-HIV seropositive pregnant women were enrolled in a study of maternal factors related to mother-to-infant human immunodeficiency virus type 1 (HIV-1) transmission. HIV-1 infection was documented in 11 of 45 infants (24.4%). Obstetric factors, maternal CD4 counts, and disease stage were not related to the risk of transmission. HIV-1 RNA levels at delivery were significantly higher in mothers who transmitted the infection (P = .024). A strong relationship between viral load and risk of transmission was observed in women with stage A1 (P= .006), but not in those with stages A2-A3. These results suggest that vertical transmission of HIV-1 is multifactorial and that viral load plays a major role in mothers with early-stage HIV-1 infection. |
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Authors:
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C Mazza; A Ravaggi; A Rodella; M Duse; D Padula; M Lomini; F Castelli; S Bresciani; A Albertini; E Cariani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of medical virology Volume: 58 ISSN: 0146-6615 ISO Abbreviation: J. Med. Virol. Publication Date: 1999 May |
Date Detail:
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Created Date: 1999-06-29 Completed Date: 1999-06-29 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7705876 Medline TA: J Med Virol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 59-62 Citation Subset: IM; X |
Affiliation:
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III Laboratory of Clinical Chemistry, Hospital of Brescia, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult CD4-Positive T-Lymphocytes / immunology* Female HIV Infections / immunology*, transmission*, virology HIV-1* / genetics Humans Infant, Newborn Infectious Disease Transmission, Vertical* Predictive Value of Tests Pregnancy Pregnancy Complications, Infectious / immunology*, virology Viral Load* |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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