| Influence of magnesium deficiency on liver collagen after carbon tetrachloride or ethanol administration to rats. | |
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MedLine Citation:
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PMID: 4067656 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of magnesium deficiency on liver collagen after the administration of a hepatotoxic substance were investigated. Rats, fed a control or magnesium-deficient diet (0.040 g/kg), received six CCl4 or mineral oil injections administered at 2-d intervals starting from the first day of diet treatment. They were killed 3 or 12 d after the last injection. Between postinjection d 3 and 12, no change of magnesium concentration in liver was observed in the deficient rats. Three days after the end of treatment liver calcium in the magnesium-deficient CCl4-treated rats was higher than in any other group. Liver collagen of untreated control rats and untreated magnesium-deficient rats was not significantly different. In control and magnesium-deficient animals receiving CCl4 treatment, the liver collagen levels were significantly higher than in untreated rats. The magnesium-deficient rats receiving CCl4 have higher liver collagen than the controls receiving CCl4. In a second experiment the effect of suboptimum intake of magnesium (0.120 g/kg) combined with the ingestion of ethanol was studied in rats given a solution of ethanol in water for 55 d as their only source of fluid. Mortality occurred in the magnesium-deficient rats receiving ethanol, and body weights of these rats were lower than those of animals in the other three groups. The collagen concentration in liver was higher in magnesium-deficient rats consuming ethanol than in any other group. The synergistic action between magnesium deficiency and ethanol therefore appears to be analogous to that observed with CCl4. |
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Authors:
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Y Rayssiguier; F Chevalier; M Bonnet; J Kopp; J Durlach |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: The Journal of nutrition Volume: 115 ISSN: 0022-3166 ISO Abbreviation: J. Nutr. Publication Date: 1985 Dec |
Date Detail:
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Created Date: 1986-01-23 Completed Date: 1986-01-23 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0404243 Medline TA: J Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1656-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Body Weight / drug effects Calcium / blood, metabolism Carbon Tetrachloride / toxicity* Collagen / metabolism* Ethanol / toxicity* Liver / drug effects, metabolism* Magnesium / blood, metabolism Magnesium Deficiency / metabolism* Male Rats Rats, Inbred Strains |
| Chemical | |
Reg. No./Substance:
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56-23-5/Carbon Tetrachloride; 64-17-5/Ethanol; 7439-95-4/Magnesium; 7440-70-2/Calcium; 9007-34-5/Collagen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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