Document Detail


Influence of lung oxidant and antioxidant status on alveolarization: role of light-exposed total parenteral nutrition.
MedLine Citation:
PMID:  18474254     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Parenteral multivitamins (MVP) are linked to the generation of peroxides, which cause oxidant injury in lungs associated with alveolar remodelling linked to lung disease of prematurity. This study was to investigate the relationship between alveolar development and lung oxidant-antioxidant status as modulated by the mode of administration of multivitamins with total parenteral nutrition (TPN). Four groups of guinea pig pups received parenteral nutrition differing by 1) mode of MVP admixture: with amino acid solution (AA-MVP) or lipid emulsion (LIP-MVP); 2) light exposure: TPN exposed (LE) or shielded from light (LP). After 2 or 4 days of TPN, vitamins C and E, 8-isoprostaneF2alpha and alveolarization index were determined in lungs and GSSG/GSH in lungs and blood. Exposure to light and the mode of MVP admixture did not influence vitamin E and isoprostane levels. Blood glutathione redox potential was more oxidized in LE and LIP-MVP groups after 4-day infusions, whereas lung redox potential was more reduced in LE groups. LP and LIP-MVP had a beneficial effect, with higher number of alveoli. Globally, results indicate that in this model, alveolarization and modifications in lung redox potential are two independent events induced by light exposed TPN.
Authors:
Jean-Claude Lavoie; Thérèse Rouleau; Apollinaire Tsopmo; James Friel; Philippe Chessex
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-23
Journal Detail:
Title:  Free radical biology & medicine     Volume:  45     ISSN:  0891-5849     ISO Abbreviation:  Free Radic. Biol. Med.     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-08-11     Completed Date:  2008-10-03     Revised Date:  2011-03-25    
Medline Journal Info:
Nlm Unique ID:  8709159     Medline TA:  Free Radic Biol Med     Country:  United States    
Other Details:
Languages:  eng     Pagination:  572-7     Citation Subset:  IM    
Affiliation:
Department of Paediatrics, CHU Sainte-Justine, University of Montréal, Montréal, Qc, Canada H3T 1C5. jean-claude.lavoie@recherche-ste-justine.qc.ca
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MeSH Terms
Descriptor/Qualifier:
Animals
Antioxidants / metabolism*
Ascorbic Acid / metabolism
Glutathione / blood
Guinea Pigs
Isoprostanes / metabolism
Light*
Lung / blood supply*,  metabolism*
Oxidants / metabolism*
Oxidation-Reduction
Parenteral Nutrition, Total*
Peroxides
Pulmonary Alveoli / blood supply,  metabolism*
Vitamin E / metabolism
Chemical
Reg. No./Substance:
0/Antioxidants; 0/Isoprostanes; 0/Oxidants; 0/Peroxides; 1406-18-4/Vitamin E; 50-81-7/Ascorbic Acid; 70-18-8/Glutathione

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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