Document Detail

Influence of low-dose polyunsaturated fatty acids supplementation on the inflammatory response of healthy adults.
MedLine Citation:
PMID:  17664057     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The aim of the present study was to examine the immune-modulating effect of two different fat blends enriched with a low dose of anti- or proinflammatory polyunsaturated fatty acids on the fatty acid status and subsequently on the immune response of healthy volunteers. METHODS: Thirty healthy volunteers were randomly assigned to group A (anti-inflammatory blend rich in polyunsaturated fatty acids: alpha-linolenic acid, 240 mg/d; eicosapentaenoic acid, 120 mg/d; stearidonic acid, 49 mg/d; and gamma-linolenic acid, 73 mg/d) or group B (arachidonic acid, 40 mg/d; containing an inflammatory fat blend) for a 2-wk dietary supplementation period. Concentrations of interleukin-8, interleukin-10, tumor necrosis factor-alpha, prostaglandins E(1) and E(2), and leukotriene B(4) were investigated before, after 2 wk of supplementation, and 2 wk after stopping supplementation using a whole blood ex vivo lipopolysaccharide-stimulation assay. RESULTS: Plasma concentrations of alpha-linolenic acid and eicosapentaenoic acid were significantly increased in group A. In addition, dietary fat blends influenced eicosapentaenoic acid concentration in erythrocyte membranes. Supplementation of the fat blends resulted in contrasting effects on the expression of lipid mediators and cytokines after ex vivo lipopolysaccharide stimulation. Release of prostaglandin E(1) and leukotriene B(4) were significantly decreased in group A, whereas prostaglandin E(2) and interleukin-10 concentrations were significantly increased in group B. No effect on interleukin-8 or tumor necrosis factor-alpha release was found after supplementation with either fat blend. CONCLUSIONS: These results show an immune-modulating effect of a low-dose dietary polyunsaturated fatty acid supplementation. However, further studies regarding fat-blend composition and period of supplementation in patients with inflammatory conditions are required.
Ralf Schubert; Richard Kitz; Christopher Beermann; Markus Andreas Rose; Patrick Carolus Baer; Stefan Zielen; Hansjosef Boehles
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Publication Detail:
Type:  Journal Article; Randomized Controlled Trial     Date:  2007-07-30
Journal Detail:
Title:  Nutrition (Burbank, Los Angeles County, Calif.)     Volume:  23     ISSN:  0899-9007     ISO Abbreviation:  Nutrition     Publication Date:  2007 Oct 
Date Detail:
Created Date:  2007-09-17     Completed Date:  2007-12-03     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8802712     Medline TA:  Nutrition     Country:  United States    
Other Details:
Languages:  eng     Pagination:  724-30     Citation Subset:  IM    
Department of Pediatrics, J. W. Goethe University, Frankfurt/Main, Germany.
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MeSH Terms
Alprostadil / blood
Dietary Supplements
Dinoprostone / blood
Double-Blind Method
Eicosanoic Acids / blood*
Erythrocyte Membrane / chemistry
Fatty Acids, Omega-3 / administration & dosage,  blood,  pharmacology
Fatty Acids, Omega-6 / administration & dosage,  blood,  pharmacology
Fatty Acids, Unsaturated / administration & dosage,  blood*,  pharmacology*
Inflammation / blood*
Interleukin-10 / blood
Interleukin-8 / blood
Leukotriene B4
Time Factors
Tumor Necrosis Factor-alpha / blood
alpha-Linolenic Acid / blood*
Reg. No./Substance:
0/Eicosanoic Acids; 0/Fatty Acids, Omega-3; 0/Fatty Acids, Omega-6; 0/Fatty Acids, Unsaturated; 0/Interleukin-8; 0/Tumor Necrosis Factor-alpha; 130068-27-8/Interleukin-10; 363-24-6/Dinoprostone; 463-40-1/alpha-Linolenic Acid; 71160-24-2/Leukotriene B4; 745-65-3/Alprostadil

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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