| Influence of loss of function MC1R variants in genetic susceptibility of familial melanoma in Spain. | |
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MedLine Citation:
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PMID: 20539244 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We explored the presence of germline alterations in CDK4 exon 2, CDKN2A and MC1R in a hospital-based study of 89 melanoma cases from 89 families with at least two members affected by cutaneous melanoma. A total of 30% of the melanoma kindreds studied were carriers of CDKN2A variants, and three of these variants were known predominant alleles that have been identified earlier in Mediterranean populations (p.G101W, p.V59G and c.358delG). We observed a higher frequency of nonsynonymous MC1R variants in these Spanish melanoma kindreds (72%) with respect to the general population (60%). We observed a higher frequency of nonsynonymous MC1R variants in this Spanish melanoma kindred (72%) respect to general population (60%). A new classification of MC1R variants based on their functional effects over melanocortin-1 receptor, including the dominant-negative effect of some of them in heterozygotes, suggested an association of loss of function MC1R variants and multiple primary melanoma cases from melanoma kindred (odds ratio: 6.07, 95% confidence interval: 1.35-27.20). This study proposes the relevance of loss of function MC1R variants in the risk of melanoma in multiple primary melanoma cases with family history from areas with low melanoma incidence rate. |
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Authors:
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Carlos de Torre; Zaida Garcia-Casado; Jorge A Martínez-Escribano; Rafael Botella-Estrada; Jose Bañuls; Vicente Oliver; Pedro Mercader; Jose M Azaña; Javier Frias; Eduardo Nagore |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Melanoma research Volume: 20 ISSN: 1473-5636 ISO Abbreviation: Melanoma Res. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-08 Completed Date: 2010-10-25 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9109623 Medline TA: Melanoma Res Country: England |
Other Details:
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Languages: eng Pagination: 342-8 Citation Subset: IM |
Affiliation:
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Research Unit, Hospital Universitario Virgen de la Arrixaca, Spain. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclin-Dependent Kinase 4
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genetics Exons Genes, p16 Genetic Predisposition to Disease Genetic Variation Germ-Line Mutation Humans Melanoma / genetics* Mutation Phenotype Polymorphism, Genetic Receptor, Melanocortin, Type 1 / genetics* Skin Neoplasms / genetics* Spain |
| Chemical | |
Reg. No./Substance:
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0/Receptor, Melanocortin, Type 1; EC 2.7.1.37/CDK4 protein, human; EC 2.7.11.22/Cyclin-Dependent Kinase 4 |
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