Document Detail


Influence of loperamide and loperamide oxide on the anal sphincter. A manometric study.
MedLine Citation:
PMID:  1511646     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The objective of this study was to investigate the effects of the opioid loperamide and its recently synthesized pharmacologically inactive prodrug loperamide oxide on the anal sphincter. In a double-blind, placebo-controlled crossover study, anorectal manometry was performed in 12 healthy volunteers five hours after oral bolus application of 10 mg of loperamide, loperamide oxide, or placebo. Loperamide significantly increased the threshold volumes for minimal perception and urgency to defecate (P less than 0.05) and raised the volume required to abolish recovery of the rectoanal inhibitory reflex (P less than 0.05). These findings suggest that loperamide has a specific continence-improving action on the anal sphincter. However, anal resting pressure and maximal squeeze pressure were unaffected in our study and do not seem to be responsible for this effect. The effects under loperamide oxide showed a similar tendency but were without statistical significance.
Authors:
M Göke; K Ewe; K Donner; K H Meyer zum Büschenfelde
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Publication Detail:
Type:  Clinical Trial; Controlled Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  Diseases of the colon and rectum     Volume:  35     ISSN:  0012-3706     ISO Abbreviation:  Dis. Colon Rectum     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-09-29     Completed Date:  1992-09-29     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0372764     Medline TA:  Dis Colon Rectum     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  857-61     Citation Subset:  IM    
Affiliation:
I. Department of Medicine, University of Mainz, Germany.
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MeSH Terms
Descriptor/Qualifier:
Adult
Anal Canal / drug effects*,  physiology
Defecation / drug effects
Double-Blind Method
Female
Humans
Loperamide / analogs & derivatives*,  pharmacology*
Male
Manometry
Pressure
Rectum / drug effects,  physiology
Chemical
Reg. No./Substance:
106900-12-3/loperamide oxide; 53179-11-6/Loperamide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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