Document Detail

Influence of local anaesthetics on the aggregation and deformability of erythrocytes.
MedLine Citation:
PMID:  11185679     Owner:  NLM     Status:  MEDLINE    
The effects of two local anaesthetics, procain and tetracaine, on erythrocyte aggregation and deformability under in vitro conditions are analysed. Fresh blood samples from healthy volunteers are obtained by venepuncture in test tubes containing heparin as anticoagulant. After centrifugation, plasma and cells are separated and buffy coat is discarded. The erythrocyte suspensions for aggregation and deformability measurement are prepared at hematocrit 34 and at 8% in buffered medium containing glucose and albumin, respectively. A part of the suspending medium in these samples is replaced by an equal volume of anaesthetic solution to obtain its final concentration ranging from 0.001 to 1 g/l. The results show that with the increase of anaesthetic concentration the deformability index and the aggregation index are reduced. The change in erythrocyte shape may contribute to the decrease in aggregation. The combined effect of these parameters may affect blood flow under varied experimental conditions.
S Ramakrishnan; R Grebe; M Singh; H Schmid-Schönbein
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Clinical hemorheology and microcirculation     Volume:  20     ISSN:  1386-0291     ISO Abbreviation:  Clin. Hemorheol. Microcirc.     Publication Date:  1999  
Date Detail:
Created Date:  2001-01-17     Completed Date:  2001-03-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9709206     Medline TA:  Clin Hemorheol Microcirc     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  21-6     Citation Subset:  IM    
Institute of Physiology, Klinikum der RWTH, Aachen, Germany.
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MeSH Terms
Anesthetics, Local / pharmacology*
Cell Culture Techniques
Dose-Response Relationship, Drug
Erythrocyte Aggregation / drug effects
Erythrocyte Deformability / drug effects
Erythrocytes / cytology,  drug effects*,  physiology
Procaine / pharmacology*
Tetracaine / pharmacology
Reg. No./Substance:
0/Anesthetics, Local; 59-46-1/Procaine; 94-24-6/Tetracaine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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