Document Detail

Influence of liver metabolism on the actions of althesin and thiopentone.
MedLine Citation:
PMID:  1191478     Owner:  NLM     Status:  MEDLINE    
To examine the role of liver metabolism on the actions of Althesin, its duration of action and circulatory effects were measured under the following experimental conditions in the rat: (a) non pretreated rats; (b) non pretreated rats: injection through the portal vein; (c) rats with cholestasis; (d) rats with induced microsomal enzymes; (e) rats with a depressed microsomal enzymatic synthesis. The experiments were repeated in the same animals by injecting equivalent doses of thiopentone. The effects of Althesin depend upon the functional conditions of the liver, while a relationship of this kind does not occur with thiopentone.
G P Novelli; M Marsili; P Lorenzi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British journal of anaesthesia     Volume:  47     ISSN:  0007-0912     ISO Abbreviation:  Br J Anaesth     Publication Date:  1975 Sep 
Date Detail:
Created Date:  1976-02-19     Completed Date:  1976-02-19     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0372541     Medline TA:  Br J Anaesth     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  913-6     Citation Subset:  IM    
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MeSH Terms
Alfaxalone Alfadolone Mixture / administration & dosage,  metabolism,  pharmacology*
Blood Pressure / drug effects
Cholestasis / metabolism
Enzyme Induction
Heart Rate / drug effects
Liver / metabolism*
Microsomes, Liver / enzymology
Portal Vein
Pregnanediones / pharmacology*
Sleep / drug effects
Thiopental / administration & dosage,  metabolism,  pharmacology*
Reg. No./Substance:
0/Pregnanediones; 76-75-5/Thiopental; 8067-82-1/Alfaxalone Alfadolone Mixture

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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