Document Detail

Influence of lithium on cell function in two different cell systems.
MedLine Citation:
PMID:  12859019     Owner:  NLM     Status:  MEDLINE    
Lithium is widely used in the treatment and prophylaxis of bipolar psychiatric disorders. It accumulates in the thyroid gland and can cause goitre or thyroid dysfunction. The mechanisms of various effects of the lithium ion on thyroid cells have not been completely clarified. The aim of our work was to establish whether lithium, in the presence or absence of TSH, stimulates the synthesis of cAMP; as model systems we used a strain of rat thyroid follicular cells FRTL-5 and a line of Chinese hamster ovary fibroblasts with the human TSH receptor (CHO-R). Lithium at concentrations of 0.35 mM, 1 mM, 1.4 mM, 1.7 mM and 2 mM without TSH and at selected concentrations with TSH stimulation significantly increased cAMP synthesis in FRTL-5 and in CHO-R cells when compared with controls without lithium. These results are different from the published data, which have been unable to confirm the influence of lithium on cAMP synthesis or have even reported the inhibition of cAMP synthesis. However, in most published investigations only lithium in combination with TSH was tested. In conclusion, lithium was found to stimulate cAMP synthesis in FRTL-5 cells and in CHO-R cells.
S Gaberscek; M Kalisnik; K Pavlin; M Pezdirc; S Hojker
Related Documents :
1729419 - Phorbol esters cause preferential secretion of norepinephrine from bovine chromaffin ce...
2773669 - Developing rat cerebellum--iii. effects of abnormal thyroid states and undernutrition o...
12197669 - Immunolocalization of centriole-associated striated rootlets in human submandibular gla...
22641959 - Histologic classification of penile intraepithelial neoplasia.
8607289 - Evaluation of the role of mammalian thyroid parafollicular cells.
6478629 - Thyroglobulin secretion by human thyroid cells after monolayer culture--comparison of n...
23657259 - Psl trails guide exploration and microcolony formation in pseudomonas aeruginosa biofilms.
10862889 - Yeast cell attachment: a tool modulating wall composition and resistance to 5-bromo-6-a...
20089319 - Microalgae response to petroleum spill: an experimental model analysing physiological a...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Folia biologica     Volume:  49     ISSN:  0015-5500     ISO Abbreviation:  Folia Biol. (Praha)     Publication Date:  2003  
Date Detail:
Created Date:  2003-07-15     Completed Date:  2004-03-08     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  0234640     Medline TA:  Folia Biol (Praha)     Country:  Czech Republic    
Other Details:
Languages:  eng     Pagination:  110-4     Citation Subset:  IM    
University Medical Centre Ljubljana, Department for Nuclear Medicine, Ljubljana, Slovenia.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Antipsychotic Agents / pharmacology
CHO Cells
Cell Line
Cyclic AMP / biosynthesis,  metabolism
Dose-Response Relationship, Drug
Lithium / pharmacology*
Thyroid Gland / cytology
Thyrotropin / metabolism
Reg. No./Substance:
0/Antipsychotic Agents; 60-92-4/Cyclic AMP; 7439-93-2/Lithium; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Intraembryonic avian leukosis virus subgroup C (ALV-C) inoculation producing wasting disease in duck...
Next Document:  Xstir polymorphism and absence of sex linkage in Xenopus laevis ME2 gene.