| Influence of lithium on cell function in two different cell systems. | |
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MedLine Citation:
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PMID: 12859019 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Lithium is widely used in the treatment and prophylaxis of bipolar psychiatric disorders. It accumulates in the thyroid gland and can cause goitre or thyroid dysfunction. The mechanisms of various effects of the lithium ion on thyroid cells have not been completely clarified. The aim of our work was to establish whether lithium, in the presence or absence of TSH, stimulates the synthesis of cAMP; as model systems we used a strain of rat thyroid follicular cells FRTL-5 and a line of Chinese hamster ovary fibroblasts with the human TSH receptor (CHO-R). Lithium at concentrations of 0.35 mM, 1 mM, 1.4 mM, 1.7 mM and 2 mM without TSH and at selected concentrations with TSH stimulation significantly increased cAMP synthesis in FRTL-5 and in CHO-R cells when compared with controls without lithium. These results are different from the published data, which have been unable to confirm the influence of lithium on cAMP synthesis or have even reported the inhibition of cAMP synthesis. However, in most published investigations only lithium in combination with TSH was tested. In conclusion, lithium was found to stimulate cAMP synthesis in FRTL-5 cells and in CHO-R cells. |
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Authors:
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S Gaberscek; M Kalisnik; K Pavlin; M Pezdirc; S Hojker |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Folia biologica Volume: 49 ISSN: 0015-5500 ISO Abbreviation: Folia Biol. (Praha) Publication Date: 2003 |
Date Detail:
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Created Date: 2003-07-15 Completed Date: 2004-03-08 Revised Date: 2005-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0234640 Medline TA: Folia Biol (Praha) Country: Czech Republic |
Other Details:
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Languages: eng Pagination: 110-4 Citation Subset: IM |
Affiliation:
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University Medical Centre Ljubljana, Department for Nuclear Medicine, Ljubljana, Slovenia. simona.gaberscek@kclj.si |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antipsychotic Agents / pharmacology CHO Cells Cell Line Cricetinae Cyclic AMP / biosynthesis, metabolism Dose-Response Relationship, Drug Lithium / pharmacology* Rats Thyroid Gland / cytology Thyrotropin / metabolism |
| Chemical | |
Reg. No./Substance:
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0/Antipsychotic Agents; 60-92-4/Cyclic AMP; 7439-93-2/Lithium; 9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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