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Influence of lipids with hydroxyl-containing head groups on Fe(2+) (Cu(2+))/H2O2-mediated transformation of phospholipids in model membranes.
MedLine Citation:
PMID:  24189590     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Under condition of ROS formation in lipid membranes, free radical reactions can proceed in, both hydrophobic (peroxidation of lipids, POL) and polar (free radical fragmentation) parts of the, bilayer. Free- -position, with respect to an ester or amide bond. The present study has been undertaken to investigate freeradical, transformations of phospholipids in model membranes containing lipids able to undergo, fragmentation in their polar part. Liposomes from egg yolk lecithin containing saturated or, monounsaturated glycero- and sphingolipids were subjected to the action of an HO* - generating, system - Fe2+(Cu2+)/H2O2/Asc, and the POL products were investigated. In parallel with this, the, effects of monoacylglycerols and scavengers of reactive species on Fe2+(Cu2+)/H2O2/Asc - mediated, free-radical fragmentation of phosphatidylglycerols were studied. Hydroxyl-containing sphingolipids, and glycerolipids, which undergo free-radical fragmentation under such conditions, manifested, antioxidant properties in the model membranes. In the absence of HO groups in the lipid structure, the, effect was either pro-oxidant or neutral. Monoacylglycerols slowed down the rate of both peroxidation, in the hydrophobic part and free-radical fragmentation in the hydrophilic part of phospholipid, membrane. Scavengers of reactive species inhibited the fragmentation of phosphatidylglycerol, substantially. Thus, the ability of hydroxyl-containing lipids to undergo free-radical fragmentation in, polar part apparently makes a substantial contribution to the mechanism of their protector action.
Authors:
Viktoriya N Olshyk; Inna V Melsitova; Irina L Yurkova
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2013-11-1
Journal Detail:
Title:  Chemistry and physics of lipids     Volume:  -     ISSN:  1873-2941     ISO Abbreviation:  Chem. Phys. Lipids     Publication Date:  2013 Nov 
Date Detail:
Created Date:  2013-11-5     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0067206     Medline TA:  Chem Phys Lipids     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2013 Jiang Xu The Authors. Published by Elsevier Ireland Ltd.. All rights reserved.
Affiliation:
Department of Chemistry, Belarusian State University, Minsk, Belarus.
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