| Influence of linoleic acid in the diet on arterial pressure of salt loaded rats. II. Effects on plasma catecholamine concentration, renin activity, and reactivity of isolated vessels. | |
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MedLine Citation:
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PMID: 742304 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. A linoleic acid free diet and indomethacin treatment induce an increase in the epinephrine and norepinephrine concentrations in the plasma. 2. The renin activities in the kidney and plasma were increased by a linoleic acid free diet and decreased by indomethacin treatment. 3. The reactivity of isolated blood vessels to norepinephrine, angiotensin, PGE2 and PGA2 was intensified after linoleic acid free diet. Indomethacin treatment neutralized the differences between the different diet groups. We conclude that the increase in the sympathetic activity, in the renin activity and in the vasoreactivity after a linoleic acid free diet has promoted the elevation of blood pressure of salt loaded rats and that these prohypertensive changes have been caused by a diminished PG biosynthesis in kidneys and blood vessels. |
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Authors:
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L Somova; V Orbetzova; F Davidova; P Hoffmann; C Taube; K Pönicke; W Förster |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta biologica et medica Germanica Volume: 37 ISSN: 0001-5318 ISO Abbreviation: Acta Biol. Med. Ger. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370276 Medline TA: Acta Biol Med Ger Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 869-73 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Angiotensins
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pharmacology Animals Blood Pressure / drug effects* Catecholamines / blood* Dietary Fats* Epinephrine / blood Indomethacin / pharmacology Kidney / drug effects, metabolism* Linoleic Acids / pharmacology* Male Norepinephrine / pharmacology Prostaglandins A / pharmacology Prostaglandins E / pharmacology Rats Renin / metabolism* Sodium Chloride / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Angiotensins; 0/Catecholamines; 0/Dietary Fats; 0/Linoleic Acids; 0/Prostaglandins A; 0/Prostaglandins E; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 53-86-1/Indomethacin; 7647-14-5/Sodium Chloride; EC 3.4.23.15/Renin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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