Document Detail

Influence of linoleic acid in the diet on arterial pressure of salt loaded rats. II. Effects on plasma catecholamine concentration, renin activity, and reactivity of isolated vessels.
MedLine Citation:
PMID:  742304     Owner:  NLM     Status:  MEDLINE    
1. A linoleic acid free diet and indomethacin treatment induce an increase in the epinephrine and norepinephrine concentrations in the plasma. 2. The renin activities in the kidney and plasma were increased by a linoleic acid free diet and decreased by indomethacin treatment. 3. The reactivity of isolated blood vessels to norepinephrine, angiotensin, PGE2 and PGA2 was intensified after linoleic acid free diet. Indomethacin treatment neutralized the differences between the different diet groups. We conclude that the increase in the sympathetic activity, in the renin activity and in the vasoreactivity after a linoleic acid free diet has promoted the elevation of blood pressure of salt loaded rats and that these prohypertensive changes have been caused by a diminished PG biosynthesis in kidneys and blood vessels.
L Somova; V Orbetzova; F Davidova; P Hoffmann; C Taube; K Pönicke; W Förster
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta biologica et medica Germanica     Volume:  37     ISSN:  0001-5318     ISO Abbreviation:  Acta Biol. Med. Ger.     Publication Date:  1978  
Date Detail:
Created Date:  1979-04-25     Completed Date:  1979-04-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0370276     Medline TA:  Acta Biol Med Ger     Country:  GERMANY, EAST    
Other Details:
Languages:  eng     Pagination:  869-73     Citation Subset:  IM    
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MeSH Terms
Angiotensins / pharmacology
Blood Pressure / drug effects*
Catecholamines / blood*
Dietary Fats*
Epinephrine / blood
Indomethacin / pharmacology
Kidney / drug effects,  metabolism*
Linoleic Acids / pharmacology*
Norepinephrine / pharmacology
Prostaglandins A / pharmacology
Prostaglandins E / pharmacology
Renin / metabolism*
Sodium Chloride / pharmacology*
Reg. No./Substance:
0/Angiotensins; 0/Catecholamines; 0/Dietary Fats; 0/Linoleic Acids; 0/Prostaglandins A; 0/Prostaglandins E; 51-41-2/Norepinephrine; 51-43-4/Epinephrine; 53-86-1/Indomethacin; 7647-14-5/Sodium Chloride; EC

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