| Influence of linoleic acid content of the diet on arterial pressure of salt loaded rats. I. Effects on prostaglandin metabolism and sympathetic nervous system. | |
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MedLine Citation:
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PMID: 742303 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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1. Compared with linoleic acid rich and pellet diet linoleic acid free diet causes an increase in blood pressure in salt loaded rats. The blood pressure increasing effect of linoleic acid poor diet could not be augmented by linoleic acid free diet. 2. The blood pressure was increased by indomethacin in linoleic acid rich and pellet fed rats. In linoleic acid free fed animals indomethacin shows only a brief augmentation of blood pressure. 3. Prostaglandin (PG) biosynthesis was decreased in isolated kidneys and aorta but increased in the kidney medulla homogenate after a four-week linoleic acid free diet. 4.. Chemical sympathectomy by intracerebroventricular injections of 6-hydroxydopamine abolished the blood pressure increasing effect of linoleic acid free diet. We postulate that changes in the PG metabolism and in the activity of sympathetic nervous system are causes for the elevated blood pressure of linoleic acid free fed salt loaded rats and we conclude that the function of the cardiovascular system is influenced favourably by a linoleic acid rich diet. |
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Authors:
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P Hoffmann; C Taube; K Pönicke; W Förster; L Somova; V Orbetzova; F Davidova |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Acta biologica et medica Germanica Volume: 37 ISSN: 0001-5318 ISO Abbreviation: Acta Biol. Med. Ger. Publication Date: 1978 |
Date Detail:
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Created Date: 1979-04-25 Completed Date: 1979-04-25 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0370276 Medline TA: Acta Biol Med Ger Country: GERMANY, EAST |
Other Details:
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Languages: eng Pagination: 863-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Aorta / drug effects, metabolism Blood Pressure / drug effects* Dietary Fats* Indomethacin / pharmacology Kidney / drug effects, metabolism Linoleic Acids / pharmacology* Male Prostaglandins / metabolism* Rats Sodium Chloride / pharmacology* |
| Chemical | |
Reg. No./Substance:
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0/Dietary Fats; 0/Linoleic Acids; 0/Prostaglandins; 53-86-1/Indomethacin; 7647-14-5/Sodium Chloride |
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