Document Detail

Influence of ketanserin, an antihypertensive agent with specific 5-HT2-receptor blocking activity, on intracranial pressure.
MedLine Citation:
PMID:  6140126     Owner:  NLM     Status:  MEDLINE    
During administration of ketanserin, a selective 5-HT2-receptor blocker, intracranial pressure (ICP) was measured in dogs without (group 1) and with (group 2) intracranial hypertension (ICP greater than 20 mm Hg). A bolus of 1 mg/kg body weight and subsequent infusion of 13.25 +/- 1.2 mg/kg of ketanserin decreased mean arterial pressure 35% +/- 18% in group 1 and 35% +/- 19% in group 2. In both groups, there was no change in ICP or in ventricular volume-pressure response curves (intracranial compliance [ICC]) after the administration of ketanserin. Ketanserin may be a safe antihypertensive drug for avoiding and treating hypertension in neurosurgical patients.
H Van Aken; C Anger; C Puchstein; J Thijs; P Lawin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Critical care medicine     Volume:  12     ISSN:  0090-3493     ISO Abbreviation:  Crit. Care Med.     Publication Date:  1984 Jan 
Date Detail:
Created Date:  1984-02-22     Completed Date:  1984-02-22     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0355501     Medline TA:  Crit Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  4-7     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Gas Analysis
Cardiac Output / drug effects
Cerebral Cortex / blood supply
Hemodynamics / drug effects
Histamine H2 Antagonists / pharmacology*
Intermittent Positive-Pressure Ventilation
Intracranial Pressure / drug effects*
Piperidines / pharmacology*
Reg. No./Substance:
0/Histamine H2 Antagonists; 0/Piperidines; 74050-98-9/Ketanserin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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