| Influence of kavain on hepatic ultrastructure. | |
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MedLine Citation:
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PMID: 18203285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To investigate whether the major kavalactone kavain imposes adverse effects on the liver ultrastructure and function by affecting vascular and microvascular architecture and altering hepatocellular morphology. METHODS: Kavain solution (10 microg/mL or 43.5 micromol/L) was perfused for 2 h in isolated rat livers. After standard fixation and tissue preparation, the samples were examined by scanning electron microscopy (SEM), transmission electron microscopy (TEM), and light microscopy (LM). RESULTS: LM, SEM, and TEM examinations indicated kavain-treated rat livers (n=4) displayed severe vascular and endothelial damage compared to control livers (n=4). CONCLUSION: The data so far support the hypothesis that kavain induces adverse effects on liver; additional investigations with other kavalactones and their effects on liver are urgently needed. |
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Authors:
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Shuang Fu; Emine Korkmaz; Filip Braet; Quan Ngo; Iqbal Ramzan |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 14 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-18 Completed Date: 2008-04-24 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 541-6 Citation Subset: IM |
Affiliation:
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Faculty of Pharmacy, The University of Sydney, NSW 2006, Australia. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Anti-Anxiety Agents / chemistry, toxicity* Liver / drug effects*, pathology*, ultrastructure Male Microscopy, Electron, Scanning Microscopy, Electron, Transmission Pyrones / chemistry, toxicity* Rats Rats, Sprague-Dawley |
| Chemical | |
Reg. No./Substance:
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0/Anti-Anxiety Agents; 0/Pyrones; 1635-33-2/kavain |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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