| Influence of iron-deficiency anemia on selected thymus functions in mice: thymulin biological activity, T-cell subsets, and thymocyte proliferation. | |
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MedLine Citation:
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PMID: 2305709 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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To define the effects of iron deficiency on thymulin biological activity, T-cell subsets, and thymocyte proliferation, C57BL/6 female mice at weaning were fed an iron-deficient diet (10 mg Fe/kg diet), an iron-sufficient diet (50 mg Fe/kg diet), or restricted amounts of the iron-sufficient diet (the pair-fed group) for 40 d. Iron deficiency did not reduce the concentration of either serum or intracytoplasmic thymulin. Although T-cell subsets in the thymus were not altered, both the cortical and medullar regions were depleted of thymocytes. In the spleen iron deficiency (but not underfeeding) significantly reduced the percentage of L3T4+ cells, of Lyt-2+ cells, and thus of the overall T-cell population. However, it did not affect the ratio of L3T4+ to Lyt-2+ T cells. Thymocyte proliferation was significantly reduced at the concanavalin A (Con A) dose (10 mg/L) that produced maximal stimulation in control and pair-fed mice but not at low (7.5 mg/L) or high (15 mg/L) Con A concentrations. We conclude that the impairment in immune functions associated with iron deficiency is not due to an impairment in thymic endocrine function but rather to decreased immunocompetent lymphocytes. |
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Authors:
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S Kuvibidila; M Dardenne; W Savino; F Lepault |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of clinical nutrition Volume: 51 ISSN: 0002-9165 ISO Abbreviation: Am. J. Clin. Nutr. Publication Date: 1990 Feb |
Date Detail:
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Created Date: 1990-03-21 Completed Date: 1990-03-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0376027 Medline TA: Am J Clin Nutr Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 228-32 Citation Subset: AIM; IM |
Affiliation:
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INSERM U-1. Unité de Recherches sur la Nutrition et l'Alimentation, Hôpital Bichat, Paris, France. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anemia, Hypochromic
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diet therapy,
immunology*,
pathology Animals Antibody Formation B-Lymphocytes / cytology Body Weight Cell Division Diet* Female Immunity, Cellular Mice Mice, Inbred C57BL Nutritional Status Organ Size T-Lymphocytes / cytology* Thymic Factor, Circulating / analysis* Thymus Gland / immunology*, pathology Thymus Hormones / analysis* |
| Chemical | |
Reg. No./Substance:
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0/Thymus Hormones; 78922-62-0/Thymic Factor, Circulating |
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