| Influence of intravenous propofol sedation on anorectal manometry in healthy adults. | |
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MedLine Citation:
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PMID: 19525661 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: We aimed to determine whether conscious sedation by propofol could affect anorectal manometry. METHODS: Eighteen healthy subjects underwent anorectal manometry at baseline and during conscious sedation by propofol. Sedation levels were monitored by auditory-evoked potentials. RESULTS: All subjects showed a normal rectoanal inhibitory reflex (RAIR) before conscious sedation. During conscious sedation, the resting anal sphincter pressure was significantly lower compared with that before conscious sedation (15 +/- 2 versus 42 +/- 4 mm Hg, P < 0.001). RAIR was present in all subjects during conscious sedation. There was no difference in threshold volume inducing RAIR before and during conscious sedation (P = NS). The level of auditory-evoked potentials did not correlate well with any of the anorectal parameters. CONCLUSIONS: Propofol significantly reduces the resting anal sphincter pressure without affecting RAIR. The inability to obtain useful data in anorectal sensation and sphincter pressure might limit the utility of propofol as a sedation agent for performing anorectal manometry. |
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Authors:
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Tso-Tsai Liu; Chih-Hsun Yi; Chien-Lin Chen; Hsu-Tang Liu; Tsung-Ying Chen |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: The American journal of the medical sciences Volume: 337 ISSN: 0002-9629 ISO Abbreviation: Am. J. Med. Sci. Publication Date: 2009 Jun |
Date Detail:
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Created Date: 2009-06-17 Completed Date: 2009-07-14 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0370506 Medline TA: Am J Med Sci Country: United States |
Other Details:
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Languages: eng Pagination: 429-31 Citation Subset: AIM; IM |
Affiliation:
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Division of Gastroenterology and Hepatology, Department of Medicine, Buddhist Tzu Chi General Hospital and University School of Medicine, Hualien 970, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anal Canal / physiology* Feasibility Studies Female Humans Hypnotics and Sedatives / administration & dosage* Infusions, Intravenous Male Manometry* Propofol / administration & dosage* Rectum / physiology* |
| Chemical | |
Reg. No./Substance:
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0/Hypnotics and Sedatives; 2078-54-8/Propofol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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