Document Detail

Influence of interleukin-6 on the development of peritumoral brain edema in meningiomas.
MedLine Citation:
PMID:  19445568     Owner:  NLM     Status:  MEDLINE    
OBJECT: Peritumoral brain edema (PTBE) is associated with perioperative neurological deficits in patients with meningiomas. However, the pathogenesis of meningioma-associated edema remains unclear. In the present study, the authors investigated the expression of interleukin-6 (IL-6) and its relationship with PTBE in resected meningiomas. METHODS: Thirty-six benign meningiomas obtained in 36 patients were studied retrospectively. Edema volume was assessed on MR images, and an edema index (EI) was calculated. Interleukin-6 mRNA and protein expression were examined by real-time reverse transcriptase polymerase chain reaction and immunohistochemical staining. RESULTS: Peritumoral brain edema was found in 16 patients (44%). Neither age, sex, histological subtype, nor tumor location were related to PTBE. The level of IL-6 mRNA was 7.72 times greater in the edema group (EI > 0.2) than in the nonedema group (EI < 0.2; p = 0.011). On immunohistochemical analysis, IL-6 protein was found localized in the cytoplasm of the tumor cells, and was detected in 12 (75%) of 16 cases of edematous meningiomas, but in only 6 (30%) of 20 nonedematous cases. There was a significant correlation between the severity of PTBE and IL-6 expression (p = 0.004). CONCLUSIONS: The authors' results in this study indicate that IL-6 expression may contribute to the development of brain edema associated with meningiomas.
Kyung-Jae Park; Shin-Hyuk Kang; Yang-Seok Chae; Mi-Ok Yu; Mi-Ok Yoo; Tai-Hyoung Cho; Jung-Keun Suh; Hoon-Kap Lee; Yong-Gu Chung
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of neurosurgery     Volume:  112     ISSN:  1933-0693     ISO Abbreviation:  J. Neurosurg.     Publication Date:  2010 Jan 
Date Detail:
Created Date:  2010-01-01     Completed Date:  2010-02-16     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0253357     Medline TA:  J Neurosurg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  73-80     Citation Subset:  AIM; IM    
Department of Neurosurgery, Korea University Anam Hospital, College of Medicine, Seoul, Korea.
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MeSH Terms
Aged, 80 and over
Brain / metabolism,  pathology,  surgery
Brain Edema / etiology*,  metabolism*,  pathology
Brain Neoplasms / metabolism,  pathology,  surgery*
Interleukin-6 / metabolism*
Magnetic Resonance Imaging
Meningioma / metabolism,  pathology,  surgery*
Middle Aged
Postoperative Complications*
RNA, Messenger / genetics,  metabolism
Retrospective Studies
Severity of Illness Index
Reg. No./Substance:
0/Interleukin-6; 0/RNA, Messenger
Erratum In:
J Neurosurg. 2010 Jan;112(1):208
Note: Yoo, Mi-Ok [corrected to Yu, Mi-Ok]

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