Document Detail


Influence of intact left atrial appendage on hemodynamic parameters of isolated guinea pig heart.
MedLine Citation:
PMID:  9753704     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
BACKGROUND: In isolated working guinea pig heart preparations using the conventional technique of cannulating the left atrium via the atrial appendage, the resulting cardiac output is often insufficiently low (15-20 ml/min). This is a problem in ischemia reperfusion studies where small absolute differences can be responsible for large relative changes comparing pre- and postischemic values. In an attempt to increase cardiac output, the left atrium was left intact in isolated working guinea pig hearts. The two techniques were compared for hemodynamic parameters and their similarity to the physiological condition. METHODS: The left atrium was cannulated either via the orifices of the pulmonary veins or via an incision in the atrial appendage with its subsequent ligation around the cannula (n = 45-46/group). After 20 min of pressure-volume work cardiac output, heart rate and oxygen partial pressures were measured and myocardial oxygen consumption and cardiac efficiency were calculated. RESULTS: Cardiac output was higher in hearts with intact atrial appendage (64 +/- 2 ml/min) than in hearts with ligated atrial appendage (33 +/- 1 ml/min). Myocardial oxygen consumption (6.1 +/- 0.2 and 8.4 +/- 0.3 micromol/min, resp.) and cardiac efficiency (12.8 +/- 0.6% and 19.9 +/- 0.8%, resp.) were significantly higher in hearts with intact left atrial appendage. CONCLUSIONS: Isolated working guinea pig hearts with an intact left auricle exhibit higher values for important hemodynamic parameters compared to a preparation technique involving ligation of the left auricle.
Authors:
P Massoudy; S Beblo; P Raschke; S Zahler; B F Becker
Related Documents :
8375414 - Cardiac diastolic abnormalities and atrial natriuretic factor in essential hypertension.
94414 - Electrophysiological and hemodynamic disturbances in a patients overdosed with disopyra...
7826554 - Cardiovascular actions of atrial natriuretic factor in sheep with cardiac failure.
2331904 - Short-term control of supraventricular tachycardia with verapamil infusion and calcium ...
25112694 - Heart rate variability and cardiovascular risk factors in adolescent boys.
2441174 - Antihypertensive and renal effects of captopril in spontaneously hypertensive rats: evi...
Publication Detail:
Type:  Comparative Study; In Vitro; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  European journal of medical research     Volume:  3     ISSN:  0949-2321     ISO Abbreviation:  Eur. J. Med. Res.     Publication Date:  1998 Oct 
Date Detail:
Created Date:  1998-12-17     Completed Date:  1998-12-17     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  9517857     Medline TA:  Eur J Med Res     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  470-4     Citation Subset:  IM    
Affiliation:
Department of Cardiovascular Surgery, German Heart Center Munich, Lazarettstr. 36, D-80636 Munich, Germany. massoudy@dhm.mhn.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Atrial Function
Blood Flow Velocity
Cardiac Output
Coronary Circulation
Guinea Pigs
Heart / anatomy & histology,  physiology*
Heart Atria / anatomy & histology
Hemodynamics / physiology*
Male
Oxygen Consumption
Perfusion

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Changes in platelet membrane glycoproteins before bone marrow transplantation and after engraftment-...
Next Document:  The analgesic effect of intravenous tenoxicam in symptomatic treatment of biliary colic: a compariso...