Document Detail

Influence of insulin on blood levels of branched chain keto and amino acids in man.
MedLine Citation:
PMID:  6353139     Owner:  NLM     Status:  MEDLINE    
Branched chain keto acids, their corresponding amino acids, glucose, glucagon, growth hormone, C-peptide and gastric inhibitory polypeptide were determined in 8 healthy subjects after an intravenous bolus injection of 0.1 U/kg insulin. Branched chain keto acids declined within 60 min, the corresponding amino acids within 20 min or later. Amino acids tended to return towards normal earlier than their keto acids. Blood glucose levels were normal 2 hr after insulin injection while keto and amino acids remained diminished for more than 3 hr. In 8 healthy controls, given physiological saline instead of insulin, the branched chain keto acids did not decline throughout the test. It is suggested that insulin diminishes blood levels of branched chain keto acids, that the intraorgan flux of branched chain keto acids is different from the flux of branched chain amino acids and that branched chain keto acids may serve to correct for hypoglycemia.
P Schauder; K Schröder; D Matthaei; H V Henning; U Langenbeck
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Metabolism: clinical and experimental     Volume:  32     ISSN:  0026-0495     ISO Abbreviation:  Metab. Clin. Exp.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-11-23     Completed Date:  1983-11-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0375267     Medline TA:  Metabolism     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  323-7     Citation Subset:  IM    
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MeSH Terms
Amino Acids, Branched-Chain / blood*
Blood Glucose / metabolism
Hormones / blood
Insulin / pharmacology*
Isoleucine / blood
Keto Acids / blood*
Leucine / blood
Valine / blood
Reg. No./Substance:
0/Amino Acids, Branched-Chain; 0/Blood Glucose; 0/Hormones; 0/Keto Acids; 11061-68-0/Insulin; 1460-34-0/alpha-keto-beta-methylvaleric acid; 61-90-5/Leucine; 7004-03-7/Valine; 73-32-5/Isoleucine; 759-05-7/alpha-ketoisovalerate; 816-66-0/alpha-ketoisocaproic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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