Document Detail


Influence of inositolhexaphosphori acid (phytic acid) on the copper distribution in tissues and the excretion of copper in rats.
MedLine Citation:
PMID:  11396776     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The aim of the present study was to investigate the effect of the administration of phytic acid on copper (Cu) concentrations in several different rat tissues. The animals used were divided into three groups: Group A (received a diet supplemented with 2% phytic acid), group B (received a diet supplemented with 10% phytic acid) and group C (control). At the end of the experiment, the animals were sacrificed and the concentration of copper was determined in the different tissues. Phytic acid significantly increased Cu concentration in the duodenum of the animals of both groups as well as in the lungs and blood of the animals of group A. The copper concentration was also increased in the uterus and bone of the animals of group B. On the other hand, the stomach copper concentration of the animals of both groups, the heart and lung copper concentrations of the animals of group B as well as the jejunum, colon and hair copper concentrations of the animals of group A were significantly decreased. Copper excretion through feces was significantly decreased in the animals of both groups, while the excretion through urine was not significantly affected by the administration of phytic acid. In conclusion, the administration of phytic acid can produce translocation and/or elimination of copper in various tissues of rats.
Authors:
V P Kotsaki-Kovatsi; L Kovatsi; G Koehler-Samouilidou; M Karavanis; E Bacoyanni
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of trace elements in medicine and biology : organ of the Society for Minerals and Trace Elements (GMS)     Volume:  14     ISSN:  0946-672X     ISO Abbreviation:  J Trace Elem Med Biol     Publication Date:  2001 Apr 
Date Detail:
Created Date:  2001-06-08     Completed Date:  2001-10-25     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  9508274     Medline TA:  J Trace Elem Med Biol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  193-7     Citation Subset:  IM    
Affiliation:
Laboratoty of Biochemistry and Toxicology, Faculty of Veterinary Medicine, Aristotle University, Thessaloniki, Macedonia, Greece.
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MeSH Terms
Descriptor/Qualifier:
Animals
Bone and Bones / metabolism
Copper / metabolism*,  pharmacokinetics
Duodenum / metabolism
Feces / chemistry
Female
Hair / metabolism
Intestines / metabolism
Lung / metabolism
Myocardium / metabolism
Phytic Acid / pharmacology*
Rats
Rats, Wistar
Stomach / metabolism
Uterus / metabolism
Chemical
Reg. No./Substance:
7440-50-8/Copper; 83-86-3/Phytic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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