Document Detail

Influence of inhibitors of ATP catabolism on myocardial recovery after ischemia.
MedLine Citation:
PMID:  3041105     Owner:  NLM     Status:  MEDLINE    
The loss of the catabolic products of adenosine triphosphate in the form of purine nucleosides and oxypurines during ischemia and subsequent reperfusion may limit adenine nucleotide regeneration. This study compared the effects of infusion of inhibitors of the major reactions involved in the degradation of adenosine triphosphate to inosine on the postischemic recovery of high energy phosphate and myocardial function. Isolated rat hearts were made totally ischemic after a 5-min infusion of p1,p5-diadenosine pentaphosphate, alpha, beta-methylene adenosine diphosphate, nitrobenzyl-6-thioinosine, or erythro-9-(2-hydroxy-3-nonyl) adenine, which are inhibitors of adenylate kinase, 5'-nucleotidase, adenosine translocase, and adenosine deaminase, respectively. Following 30 min of ischemia, only hearts infused with alpha, beta-methylene adenosine diphosphate recovered significantly better ventricular function than did the control (P less than 0.05), but all hearts had increased adenosine triphosphate and creatine phosphate regeneration (P less than 0.05). The formation and washout of greater than 30% of the total adenine pool metabolites were not prevented by any drug. Nevertheless all manipulations of adenine metabolism resulted in recruitment of high energy phosphate during preischemic infusion which may have potential benefits in elective ischemic arrest.
S M Humphrey; D G Holliss; L A Cartner
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Journal of surgical research     Volume:  43     ISSN:  0022-4804     ISO Abbreviation:  J. Surg. Res.     Publication Date:  1987 Aug 
Date Detail:
Created Date:  1987-10-01     Completed Date:  1987-10-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0376340     Medline TA:  J Surg Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  187-95     Citation Subset:  IM    
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MeSH Terms
Adenosine Deaminase / antagonists & inhibitors
Adenosine Triphosphate / metabolism*
Adenylate Kinase / antagonists & inhibitors
Coronary Circulation / drug effects
Coronary Disease / metabolism*
Enzyme Inhibitors / pharmacology*
Heart Rate / drug effects
Mitochondrial ADP, ATP Translocases / antagonists & inhibitors
Myocardium / metabolism*
Nucleotidases / antagonists & inhibitors
Rats, Inbred Strains
Reg. No./Substance:
0/Enzyme Inhibitors; 56-65-5/Adenosine Triphosphate; 9068-80-8/Mitochondrial ADP, ATP Translocases; EC Kinase; EC 3.1.3.-/Nucleotidases; EC'-Nucleotidase; EC Deaminase

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