| Influence of infection on patent ductus arteriosus and chronic lung disease in premature infants weighing 1000 grams or less. | |
| | |
MedLine Citation:
|
PMID: 8618179 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
OBJECTIVES: To test the hypotheses that (1) infection increases ductal dilatory prostaglandins and inflammatory mediators that may influence the closure of a patent ductus arteriosus (PDA), increasing the incidence of late episodes of PDA (after 7 days) and the rate of closure failures, and (2) the concurrence of PDA and infection increases the risk of chronic lung disease (CLD). METHODS: One hundred fourteen premature infants (birth weight, 500 to 1000 gm) were prospectively assessed for PDA and infection. Serum levels of 6-ketoprostaglandin F1 alpha and tumor necrosis factor alpha were measured routinely in all infants and when PDA or infection was present. Multivariate assessment of risk factors for PDA closure failure and for CLD was done by logistic regression, and expressed as an odds ratio and as 95% confidence intervals. RESULTS: Late PDA episodes were more frequent in infants with infection than in those without infection. A temporally related infection (<5 days between both diagnoses) was associated with an increased risk of PDA closure failure (odds ratio, 19.1 (confidence interval, 4 to 90)). In addition to birth weight and the severity of initial respiratory failure, PDA and infection increased the risk of CLD (odds ratio, 11.7 (confidence interval, 1.7 to 81) for PDA; odds ration, 3.1 (confidence interval, 1 to 11) for infection). Furthermore, when both factors were temporally related, they further increased the risk of CLD (odds ratio, 29.6 (confidence interval, 4.5 to >100)). Infants with infection and those with PDA had higher levels of 6-ketoprostaglandin F1 alpha than did control subjects. Levels of tumor necrosis factor alpha were also elevated in infants with infection and in those with late PDA. CONCLUSIONS: Infection adversely influences PDA outcome by increasing the risk of late ductal reopening and PDA closure failures. Increased levels of prostaglandins and tumor necrosis factor alpha in infants with infection may explain the poor PDA outcome. The concurrence of PDA and infection potentiates their negative effects on the risk of CLD. |
| | |
Authors:
|
A Gonzalez; I R Sosenko; J Chandar; H Hummler; N Claure; E Bancalari |
Related Documents
:
|
3789299 - Operative closure of patent ductus arteriosus in premature infants in the neonatal inte... 3747489 - Colonic mucosal dissection following electrocautery or laser polypectomy. 20881439 - Carina angle measurements for diagnosis of patent ductus arteriosus in preterm infants. 7796229 - Longitudinal changes in the diameter of the ductus arteriosus in ventilated preterm inf... 8152409 - Vancomycin dosing in neonatal patients: the controversy continues. 1479519 - Measurement of systolic blood pressure in the follow-up of low birth weight infants. 18762599 - Young maternal age and the risk of neonatal mortality in rural nepal. 3558139 - The maturation of the central auditory conduction in preterm infants until three months... 4000569 - Maternal and fetal plasma concentrations of ritodrine. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
|
Title: The Journal of pediatrics Volume: 128 ISSN: 0022-3476 ISO Abbreviation: J. Pediatr. Publication Date: 1996 Apr |
Date Detail:
|
Created Date: 1996-06-07 Completed Date: 1996-06-07 Revised Date: 2007-11-14 |
Medline Journal Info:
|
Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: UNITED STATES |
Other Details:
|
Languages: eng Pagination: 470-8 Citation Subset: AIM; IM |
Affiliation:
|
Department of Pediatrics, Division of Neonatology, University of Miami School of Medicine, Florida, USA. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Chronic Disease Ductus Arteriosus, Patent / complications, physiopathology* Female Humans Infant, Newborn Infant, Premature, Diseases / physiopathology* Infant, Very Low Birth Weight Infection / complications, physiopathology* Lung Diseases / complications, physiopathology* Male Prospective Studies Prostaglandins F / blood Sepsis / complications, physiopathology Tumor Necrosis Factor-alpha / analysis |
| Grant Support | |
ID/Acronym/Agency:
|
1 S10 RR06523-01/RR/NCRR NIH HHS |
| Chemical | |
Reg. No./Substance:
|
0/Prostaglandins F; 0/Tumor Necrosis Factor-alpha; 745-62-0/prostaglandin F1 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Increase in the concentration of transforming growth factor beta-1 in bronchoalveolar lavage fluid b...
Next Document: Deposition pattern of radiolabeled salbutamol inhaled from a metered-dose inhaler by means of a spac...