Document Detail

Influence of indomethacin on the regenerative process of the tail fin of teleost: morphometric and ultrastructural analysis.
MedLine Citation:
PMID:  21085794     Owner:  NLM     Status:  In-Process    
When partially amputated or severely injured, teleost fins suffer a regenerative process called epimorphic regeneration characterised by the following stages: the formation of a multistratified epidermal layer, the disorganisation and distal migration of multipotent mesenchymal cells, the proliferation of these cells in order to form the blastema, continuous proliferation of distal blastema to facilitate the growth, and differentiation of the proximal blastema in order to restore its lost structure. The regeneration of the fin is extremely sensitive to the action of some drugs that can interfere in its structure restoration. For this reason, and also based on papers relating that indomethacin can interfere somehow in the tissue restoration of many different organisms, the aim of this work is to evaluate the possible effects of this drug in three different doses in the regeneration of the teleost fish tail fin, taking into consideration the synthesis, the disposition and organisation of lepidotrichial matrix components, the restoration of actinotrichia, as well as the fin area itself. Therefore, histochemical, ultrastructural and morphometric analysis were done and it was observed that indomethacin in doses of 20 and 30 mg.L-1 caused a delay in the regenerative process of the dermal skeleton (lepidotrichia and actinotrichia) of the tail fins. These doses could have interfered, momentarily, in the process of blastemal cell differentiation in the cells responsible for the synthesis and disposition of actinotrichia and lepidotrichia or, even interfered in the signalling necessary for the recent differentiated cells to begin synthesising the components of the dermal skeleton.
P K Böckelmann; I J Bechara
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Brazilian journal of biology = Revista brasleira de biologia     Volume:  70     ISSN:  1678-4375     ISO Abbreviation:  Braz J Biol     Publication Date:  2010 Oct 
Date Detail:
Created Date:  2010-11-18     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101129542     Medline TA:  Braz J Biol     Country:  Brazil    
Other Details:
Languages:  eng     Pagination:  889-97     Citation Subset:  IM    
Departamento de Histologia e Embriologia, Instituto de Biologia – IB, Universidade Estadual de Campinas – UNICAMP, CP 6109, CEP 13083-970, Campinas, SP, Brazil.
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