Document Detail

Influence of increased circulating levels of splanchnic lysosomal enzymes on the response to myocardial ischemia.
MedLine Citation:
PMID:  1138631     Owner:  NLM     Status:  MEDLINE    
The ability of increased circulating activities of lysosomal hydrolases to disrupt myocardial cellular membranes was studied in anesthetized cats. Increased activities of lysosomal hydrolases were achieved by splanchnic artery occlusion (SAO) shock or by infusion of liver extract (LE). Myocardial ischemia (MI) was produced by ligation of the left coronary artery. Coronary artery ligation resulted in sustained S-T segment elevation associated with significant increases in plasma creatine phosphokinase (CPK) activity within 5 hours. Combinations of SAO or LE infusion did not modify the increase in either the plasma CPK activity or the S-T segment following MI. However, SAO shock or infusion of LE increased CPK loss from normal and ischemic myocardium, the loss being greater when MI was combined with infusion of LE or SAO shock. Similarly, MI plus SAO shock increased the loss of the lysosomal protease cathepsin D from normal and ischemic myocardial tissue. Moreover, cats subjected to MI and given LE inhibited increased mortality and decreased clearance of infused lysosomal hydrolases. These results indicate that conditions affecting increased plasma levels of hydrolases promote increased disruption of normal and ischemic myocardial tissue. These findings are consistent with the concept that hydrolases originating in the splanchnic viscera during shock play a role in enhancing damage to normal and ischemic myocardial tissue following coronary artery occlusion.
J A Spath; E A Reed; A M Lefer
Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Annals of surgery     Volume:  181     ISSN:  0003-4932     ISO Abbreviation:  Ann. Surg.     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-09-09     Completed Date:  1975-09-09     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372354     Medline TA:  Ann Surg     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  813-8     Citation Subset:  AIM; IM    
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MeSH Terms
Abdomen / blood supply
Cathepsins / blood
Coronary Disease / enzymology*
Creatine Kinase / blood
Liver / enzymology
Liver Extracts / adverse effects
Lysosomes / enzymology*
Myocardial Infarction / physiopathology
Myocardium / enzymology
Regional Blood Flow
Reg. No./Substance:
0/Liver Extracts; EC Kinase; EC 3.4.-/Cathepsins

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