Document Detail


Influence of in vitro test conditions on release of aspirin from commercial tablets.
MedLine Citation:
PMID:  1501078     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The influence of in vitro test conditions on the release of aspirin from commercial tablets was assessed with a USP rotating-basket dissolution apparatus. Three types of aspirin tablets were evaluated: plain, buffered, and microencapsulated. The variables investigated were stirring speed, pH, and volume and temperature of the dissolution medium. Plain tablets gave the best dissolution profiles under all experimental conditions, except at pH 3. Microencapsulated tablets showed sustained release. For all three types of tablets, faster dissolution was observed at pH 4.5 compared with that in artificial gastric juices. Increasing the stirring rate increased the dissolution rate, an effect most pronounced for plain tablets. Very similar dissolution curves were obtained when the dissolution test was conducted in 500 and 900 mL of dissolution media regardless of the pH of the media. No significant difference in dissolution profiles was observed when the effect of temperature was investigated. The dissolution data were evaluated on the basis of theoretical dissolution equations and by linear transformation of dissolution curves. Highly significant linear correlation coefficients revealed that the cube root equation could be used to describe drug release in artificial gastric juices, regardless of tablet type. When pH 4.5 buffer solution was used as the dissolution medium, different kinetic models were applicable.
Authors:
L Nikolić; Z Djurić; M Jovanović
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of pharmaceutical sciences     Volume:  81     ISSN:  0022-3549     ISO Abbreviation:  J Pharm Sci     Publication Date:  1992 Apr 
Date Detail:
Created Date:  1992-09-17     Completed Date:  1992-09-17     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  2985195R     Medline TA:  J Pharm Sci     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  386-91     Citation Subset:  IM    
Affiliation:
Department of Pharmaceutical Technology, Faculty of Pharmacy, Belgrade, Yugoslavia.
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MeSH Terms
Descriptor/Qualifier:
Aspirin / chemistry*
Chemistry, Pharmaceutical / methods*
Hydrogen-Ion Concentration
Kinetics
Solubility
Tablets / chemistry
Temperature
Chemical
Reg. No./Substance:
0/Tablets; 50-78-2/Aspirin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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