Document Detail


Influence of iloprost on eicosanoid generation and lipid levels in experimental myocardial ischemia in dogs.
MedLine Citation:
PMID:  2469084     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Anaesthetized mongrel dogs were subjected to occlusion of a coronary artery. The resulting myocardial infarction was observed for three hours. One hour after occlusion, infusion of the stable prostacyclin analogue iloprost or saline was started. In the control group myocardial infarction was associated with an increase of the ratio TXB2/6-keto-PGF1a which was abolished by iloprost treatment. After occlusion in the control group, the atherosclerosis index (TC-HDLC): HDLC was increased, but in the iloprost-treated group it was significantly decreased. The results of this study suggest that the administration of iloprost is able to prevent changes in eicosanoid metabolism and lipoprotein pattern after coronary artery occlusion in dogs.
Authors:
A Beitz; C Taube; J Beitz; H Goos; J Graff; J Nöhring; K F Lindenau; H J Mest
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Prostaglandins, leukotrienes, and essential fatty acids     Volume:  35     ISSN:  0952-3278     ISO Abbreviation:  Prostaglandins Leukot. Essent. Fatty Acids     Publication Date:  1989 Mar 
Date Detail:
Created Date:  1989-06-02     Completed Date:  1989-06-02     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  8802730     Medline TA:  Prostaglandins Leukot Essent Fatty Acids     Country:  SCOTLAND    
Other Details:
Languages:  eng     Pagination:  141-5     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Toxicology, Martin Luther University Halle-Wittenberg, GDR.
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MeSH Terms
Descriptor/Qualifier:
6-Ketoprostaglandin F1 alpha / blood
Animals
Coronary Disease / blood*
Dogs
Eicosanoic Acids / blood,  metabolism*
Epoprostenol / pharmacology*
Female
Iloprost
Lipids / blood*
Male
Prostanoic Acids / biosynthesis,  blood
Thromboxane B2 / blood
Chemical
Reg. No./Substance:
0/Eicosanoic Acids; 0/Lipids; 0/Prostanoic Acids; 35121-78-9/Epoprostenol; 54397-85-2/Thromboxane B2; 58962-34-8/6-Ketoprostaglandin F1 alpha; 78919-13-8/Iloprost

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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