Document Detail

Influence of hypoxic ventilatory response on arterial O2 saturation during maximal exercise in acute hypoxia.
MedLine Citation:
PMID:  8789578     Owner:  NLM     Status:  MEDLINE    
The aim of this study was to evaluate the influence of peripheral chemosensitivity estimated by hypoxic ventilatory response (HVR) on arterial oxygen saturation (SaO2) during maximal exercise in acute hypoxia. A group of 16 healthy men performed maximal exercise in two conditions of partial pressure of inspired oxygen (PIO2/149 and 70 mm Hg, 19.8 and 9.3 kPa). Measurements of maximal oxygen uptake (VO2max) and SaO2 using an ear-oximeter were carried out in both conditions of PIO2. The HVR was measured at rest by progressive isocapnic hypoxia and evaluated by the slope of the linear regression between the ventilatory flow (VE) and the SaO2 (delta VE/delta SaO2). The absolute value of HVR (in litres per minute per percentage saturation per kilogram) was correlated to maximal expired VE (r = 0.85, P < 0.001), ventilatory equivalent for CO2 (r = 0.83, P < 0.001) and SaO2 (r = 0.60, P < 0.05) determined during maximal exercise in hypoxia: a significant decrease in VO2max (37%) and SaO2 (32%) for PIO2 of 70 mm Hg (9.3 Pa) was observed (P < 0.001). The correlation between the decline of VO2max and arterial oxygen desaturation failed to reach statistical significance (r = 0.47, P = 0.1). The present findings indicated that the peripheral ventilatory chemosensitivity contributed to the interindividual variability of VE and SaO2 during maximal exercise in acute hypoxia.
H Benoit; T Busso; J Castells; C Denis; A Geyssant
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  European journal of applied physiology and occupational physiology     Volume:  72     ISSN:  0301-5548     ISO Abbreviation:  Eur J Appl Physiol Occup Physiol     Publication Date:  1995  
Date Detail:
Created Date:  1996-10-18     Completed Date:  1996-10-18     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0410266     Medline TA:  Eur J Appl Physiol Occup Physiol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  101-5     Citation Subset:  IM; S    
Laboratoire de physiologie-GIP Exercice, Université Jean Monnet, Saint Etienne, France.
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MeSH Terms
Anoxia / blood*
Exercise / physiology*
Oxygen / administration & dosage,  blood*
Oxygen Consumption
Respiration / physiology*
Reg. No./Substance:

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