Document Detail

Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients.
MedLine Citation:
PMID:  1132099     Owner:  NLM     Status:  MEDLINE    
The influence of a relatively small increase in serum osmolality produced by hypertonic mannitol on ventricular and systemic arterial hemodynamics and coronary blood flow was studied in 20 patients undergoing cardiac catheterization. Mannitol given to increase serum osmolality 10 mOsm resulted in a small but significant increase in mean systemic arterial pressure, maximum LV dp/dt, left ventricular end-diastolic pressure and cardiac output but no significant change in heart rate or hematocrit. The most prominent change in the patients studied, however, was in coronary blood flow which increased 39% after mannitol. Patients with severe two and three vessel coronary artery disease had increased in coronary blood flow similar to those in patients without coronary artery disease. The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease,
J T Willerson; G C Curry; J M Atkins; R Parkey; L D Horwitz
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Circulation     Volume:  51     ISSN:  0009-7322     ISO Abbreviation:  Circulation     Publication Date:  1975 Jun 
Date Detail:
Created Date:  1975-08-22     Completed Date:  1975-08-22     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0147763     Medline TA:  Circulation     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1095-100     Citation Subset:  AIM; IM    
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MeSH Terms
Blood Pressure / drug effects
Cardiac Output / drug effects
Coronary Circulation / drug effects*
Coronary Disease / drug therapy,  physiopathology*
Heart Rate / drug effects
Heart Ventricles / drug effects*,  physiopathology
Hypertonic Solutions
Mannitol / administration & dosage,  therapeutic use*
Myocardial Contraction / drug effects
Osmolar Concentration
Reg. No./Substance:
0/Hypertonic Solutions; 69-65-8/Mannitol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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