| Influence of hypertonic mannitol on ventricular performance and coronary blood flow in patients. | |
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MedLine Citation:
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PMID: 1132099 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The influence of a relatively small increase in serum osmolality produced by hypertonic mannitol on ventricular and systemic arterial hemodynamics and coronary blood flow was studied in 20 patients undergoing cardiac catheterization. Mannitol given to increase serum osmolality 10 mOsm resulted in a small but significant increase in mean systemic arterial pressure, maximum LV dp/dt, left ventricular end-diastolic pressure and cardiac output but no significant change in heart rate or hematocrit. The most prominent change in the patients studied, however, was in coronary blood flow which increased 39% after mannitol. Patients with severe two and three vessel coronary artery disease had increased in coronary blood flow similar to those in patients without coronary artery disease. The data suggest the need to further evaluate the physiological importance of the increase in coronary blood flow produced by mannitol in patients with coronary artery disease and indicate the possibility that mannitol might be of value in treating certain problems in patients with coronary artery disease, |
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Authors:
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J T Willerson; G C Curry; J M Atkins; R Parkey; L D Horwitz |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Circulation Volume: 51 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1975 Jun |
Date Detail:
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Created Date: 1975-08-22 Completed Date: 1975-08-22 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1095-100 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects Cardiac Output / drug effects Coronary Circulation / drug effects* Coronary Disease / drug therapy, physiopathology* Female Heart Rate / drug effects Heart Ventricles / drug effects*, physiopathology Hematocrit Humans Hypertonic Solutions Male Mannitol / administration & dosage, therapeutic use* Myocardial Contraction / drug effects Osmolar Concentration |
| Chemical | |
Reg. No./Substance:
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0/Hypertonic Solutions; 69-65-8/Mannitol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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